摘要
目的：观察复方小艾飞蜜膏乙醇提取物的抗炎作用。方法：分别采用二甲苯致耳肿胀、角叉菜胶致大鼠足肿胀、大鼠棉球肉芽肿、角叉菜胶致大鼠胸膜炎等炎症模型,观察复方小艾飞蜜膏抗炎活性;测定胸膜炎大鼠胸腔渗出液中总蛋白含量、血清中前列腺素E2（PGE2）与肿瘤坏死因子（TNF-α）含量,探讨其抗炎作用机制。结果：复方小艾飞蜜膏乙醇提取物在0.034~0.136g/kg的剂量范围内,能明显抑制二甲苯致耳肿胀和角叉菜胶诱导大鼠足肿胀,减轻肉芽肿的质量,有效降低胸膜炎大鼠胸腔渗出液中蛋白含量、血清中前列腺素E2（PGE2）与肿瘤坏死因子（TNF-α）含量,作用呈剂量依赖性。结论：复方小艾飞蜜膏乙醇提取物具有抗炎作用,其作用与降低PGE2和TNF-α含量有关。
Objective： To study the anti-inflammation effect of the Compound Xiaoaifeimigao. Methods： Auricle edema induced by dimethylbenzene in mice,edema in feet induced by carrageen,cotton pellet granuloma and pleurisy model induced by carrageen in rat were used for anti-inflammatory experiment. Content of protein,PGE2and TNF-α were determined. Results： Compound Xiaoaifeimigao has anti-inflammatory effect,the dose range is 0. 034 ~ 0. 136g /Kg. It could inhibit auricular edema induced by dimethylbenzene in mice,carrageenin-induced inflammation in rats and granulation induced by cotton ball in rats,and reduce the content of protein in the extravasate,PGE2and TNF-α in blood from rat pleurisy in dose-dependent manner. Conclusion： Compound Xiaoaifeimigao has anti-inflammatory effect by inhibiting the production of protein,PGE2and TNF-α.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第2期166-168,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
新疆维吾尔自治区"十二五"重大科技专项(201130105)
新疆医科大学创新基金项目(XJC201113)
关键词
复方小艾飞蜜膏
抗炎作用
Compound Xiaoaifeimigao（复方小艾飞蜜膏）
anti-inflammatory
