摘要
目的 : 研究纳米红色元素硒的护肝、抑瘤和免疫调节作用。方法 : 采用 CCl4 致小鼠急性肝损伤、S180 移植瘤和免疫模型 ,评价纳米红色元素硒的保护、抑制和调节作用。结果 : 纳米红色元素硒提高血和肝硒、抑制 CCl4 所致的肝丙二醛 (MDA)和血清天冬氨酸氨基转移酶(AST)升高 ,降低 S180 荷瘤鼠瘤重和提高 S180 荷瘤鼠的吞噬率和天然杀伤细胞 (NK)活性 ,提高正常小鼠的免疫活性 ,均有显著性差别 (P<0 .0 5)。口服 LD50 为 Se 1 1 2 .98mg/ kg bw。结论 : 纳米红色元素硒有护肝、抑瘤和免疫调节作用 。
Objective: To study the effects of nano red elemental selenium on liver protection, tumor inhibition and immune regulation. [WT5FZ]Methods: [WT5BZ]Models of acute liver injury induced by CCl 4, S 180 tumor growth and immune regulation were used. Results: Nano red elemental selenium could increase blood and liver Se contents, inhibit the increase of liver MDA and serum AST induced by CCl 4, decrease tumor weight and increase phagocytic ratio and NK cell activity in S 180 bearing mice, increase immune activities in normal mice. All these improvements were statistically significant (P<0.05). The LD 50 was 112.98 Se mg/kg bw. Conclusion: Nano red elemental selenium has the functions of liver protection, tumor inhibition and immune regulation. Its acute toxicity is the lowest among the Se preparations used so far.
出处
《营养学报》
CAS
CSCD
北大核心
2001年第1期32-35,共4页
Acta Nutrimenta Sinica
基金
国家烟草专卖局! (No.95 2 0 5 1)
