摘要
目的评价肝癌患者术前Fib-4指数对肝癌肝切除术后复发的预测价值。方法回顾性分析67例行肝部分切除肝癌患者的临床资料,根据患者术前Fib-4指数的大小分为低指数组(Fib-4指数<3.25)和高指数组(Fib-4指数≥3.25),术后应用门诊、电话方式随访,以Cox回归模型对术后复发情况进行相关因素分析。结果单因素分析提示,术前AFP≥400μg/L、肿瘤最大直径>5 cm、肿瘤数目>3个、Fib-4指数≥3.25、血管侵犯及切缘阳性、门静脉癌栓是影响肝癌肝切除术后无瘤生存的危险因素(P均<0.05),Cox回归分析显示术前Fib-4指数≥3.25、肿瘤数目>3个及门静脉癌栓是肝癌术后复发的独立危险因素(P均<0.05)。结论术前Fib-4指数≥3.25是影响肝癌患者术后复发的独立危险因素。
Objective To investigate the postoperative recurrence predictive value of preoperative Fib-4 index on hep- atocellular carcinoma patients. Methods Clinical data of 67 cases of hepatoeellular carcinoma underwent hepatectomy in the 5th Hospital Affiliated to Sun Yat-sen University were analyzed retrospectively. According to the preoperative Fib-4 in- dex, these patients were divided into 2 groups, one was Fib-4 index 〈3.25, the other was Fib-4 index≥3.25. These pa- tients were follow-up visited by using outpatient service and telephone till 2013 September. Cox ratio risk pattern analysis was used for the recurrent correlative factors. Results Univariate analysis showed that preoperative AFP≥400 ug/L, the maximum diameter of the tumor 〉 5cm, the number of tumor 〉 3, Fib-4 index ≥ 3.25, vascular invasion, positive resection margin and portal vein tumor thrombus were all risk factors of poor disease-free survival （ all P 〈 0.05 ）. Cox regression a- nalysis revealed that Fib-4 index≥3.25, the number of tumor 〉 3 and portal vein tumor thrombus were independent predic- tors of poor disease-free survival after hepateetomy for hepatocellular carcinoma （ all P 〈 0.05 ）. Conclusion Preoperative Fib-4 index≥3.25 is an independent risk factor for predicting the postoperative recurrence of patients with hepatocellular carcinoma.
出处
《山东医药》
CAS
2014年第17期4-6,共3页
Shandong Medical Journal
基金
广东省自然科学基金博士科研启动项目(10451008901004816)
关键词
肝肿瘤
Fib-4指数
术后复发
hepatocellular carcinoma
Fib-d index
postoperative recurrence
