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促代谢因子(Betatrophin):一种新的活性多肽 被引量：3

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摘要 促代谢因子(Betatrophin)主要由肝细胞表达,不仅可以通过抑制脂蛋白酯酶活性而减轻甘油三酯裂解进而升高甘油三酯水平,而且具有促进胰岛β细胞增殖的新功能。Betatrophin作为一种新发现的具有多种功能的活性多肽未来可能作为一个值得研究的心血管疾病药物作用靶点,在心血管及糖尿病研究领域具有重要意义。
作者 王嫕 秦彦文
机构地区 首都医科大学附属北京安贞医院
出处 《生理科学进展》 CAS CSCD 北大核心 2014年第2期118-120,共3页 Progress in Physiological Sciences
基金 国家自然科学基金81100222 81270389)资助课题
关键词 促代谢因子 肝癌基因相关蛋白 肝及脂肪细胞再喂诱导因子 脂蛋白酯酶抑制因子 血管紧张素样蛋白8
分类号 R335 [医药卫生—人体生理学]
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参考文献14

  • 1Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab, 2012,303 : E334 - E351.
  • 2Zhang R. Lipasin, a novel nutritionally-regulated liver-en- riched factor that regulates serum triglyceride levels. Bio- chem Biophys Res Commun, 2012,424 : 786 - 792.
  • 3Quagliarini F, Wang Y, Kozlitina J, et al. Atypical angiopoi- etin-like protein that regulates ANGPTL3. Proc Natl Acad Sci USA,2012,109 : 19751- 19756.
  • 4Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell, 2013,153 : 747 - 758.
  • 5Dong XY, Pang XW, Yu ST, et al. Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method. Int J Cancer,2004,112 : 239 - 248.
  • 6Ma R, Zhang W, Tang K,et al. Switch of glycolysis to glu- coneogenesis by dexamethasone for treatment of hepatocarei- noma. Nat Commun,2013, 4 : 2508.
  • 7Tang T, Li L, Tang J, et al. A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol, 2010, 28 : 749 - 755.
  • 8Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature, 2010,466 : 707 -713.
  • 9Zhang R, Abou-Samra AB. Emerging roles of Lipasin as a critical lipid regulator. Biochem Biophys Res Commun ,2013, 432 : 401 -405.
  • 10Musunuru K, Pirruccello JP, Do R, et al. Exome sequen- cing, ANGPTL3 mutations, and familial combined hypolip- idemia. N Engl J Med,2010,363 : 2220 -2227.

同被引文献29

  • 1Ren G,Kim JY,Smas CM.Identification of RIFL,a novel adipocyte-enriched insulin target gene with a role in lipid metabolism[J].Am J Physiol Endocrinol Metab,2012,303(3):E334-E351.
  • 2Zhang R.Lipasin,a novel nutritionally-regulated liverenriched factor that regulates serum triglyceride levels[J].Biochem Biophys Res Commun,2012,424(4):786-792.
  • 3Quagliarini F,Wang Y,Kozlitina J,et al.Atypical angiopoietin-like protein that regulates ANGPTL3[J].Proc Natl Acad Sci USA,2012,109(48):19751-19756.
  • 4Yi P,Park JS,Melton DA.Betatrophin:a hormone that controls pancreaticβcell proliferation[J].Cell,2013,153(4):747-758.
  • 5Hu H,Sun W,Yu S,et al.Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients[J].Diabetes Care,2014,37(10):2718-2722.
  • 6Zhang R,Abou-Samra AB.Emerging roles of Lipasin as a critical lipid regulator[J].Biochem Biophys Res Commun,2013,432(3):401-405.
  • 7Gusarova V,Alexa CA,Na E,et al.ANGPTL8/Betatrophin does not control pancreaticβcell expansion[J].Cell,2014,159(3):691-696.
  • 8Yi P,Park JS,Melton DA.Perspectives on the activities of ANGPTL8/betatrophin[J].Cell,2014,159(3):467-468.
  • 9Ren G,Kim JY,Smas CM.Identification of RIFL,a novel adipocyte-enriched insulin target gene with a role in lipid metabolism[J].Am J Physiol Endocrinol Metab,2012,303(3):E334-E351.
  • 10Zhang R.Lipasin,a novel nutritionally-regulated liverenriched factor that regulates serum triglyceride levels[J].Biochem Biophys Res Commun,2012,424(4):786-792.

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生理科学进展
2014年 第2期

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