摘要
肝细胞癌(hepatocellular carcinoma,HCC)是对人类健康威胁较大且常见的恶性肿瘤,其发生、进展和转归与肿瘤细胞的免疫逃逸及机体免疫系统的功能密切相关.HCC患者,尤其当病情进展至中晚期,机体免疫功能低下,致使患者生存质量降低,死亡率升高.而免疫治疗可以调节机体的免疫功能,达到减少HCC的复发转移、提高患者生存质量及延长生存期的目的,已成为HCC综合治疗的重要组成部分.故本文就HCC的免疫逃逸机制、免疫治疗实验及其临床应用研究的概况及最新研究成果作一综述.
Hepatocellular carcinoma （HCC） is a common malignant tumor as well as a big threat to human health. The occurrence, development and prognosis of HCC are closely relevant to the immune escape and immune function in HCC patients. HCC patients, especially those in the terminal stage of the disease,.have impaired immune function, which leads to reduced quality of life and raised death rate. Since immunother-apy can regulate the immune function to reduce recurrence and metastasis, improve the life quality and prolong survival, it has become an important part of comprehensive treatment for HCC. In this paper, we review the latest progress in research of immune escape mechanism and immunotherapy for primary HCC.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第15期2116-2121,共6页
World Chinese Journal of Digestology
基金
广西自然科学基金资助项目
No.桂科自0542119
广西高校优秀人才基金资助项目
No.桂教人20077029
广西卫生厅课题基金重点基金资助项目
No.桂卫重200887~~
关键词
肝细胞癌
免疫治疗
免疫逃逸
实验研究
临床应用
Hepatocellular carcinoma
Immuno-therapy
Immune escape
Experimental research
Clinical application
