摘要
目的探讨胃肠道间质瘤（GIST）的CT表现与免疫组化分型的相关性。方法回顾性分析85例CIST患者的CT影像和临床病理资料，统计病灶的部位、大小、形态、边界、生长方式、强化程度、坏死程度以及有无钙化等指标，并与免疫组化类型进行对照研究。结果85例GIST中，平滑肌方向分化26例（30．6％），神经方向分化20例（23．5％），平滑肌和神经双向分化10例（11．8％），缺乏分化特征29例（34．1％）。十二指肠GIST多为平滑肌方向分化类型。平滑肌方向分化组GIST中，病灶直径〉10cm、肿瘤显著强化和广泛坏死的比例均明显高于其他3组免疫组化类型（P〈0．05）。不同免疫组化分型GIST的形态、边界、生长方式和钙化发生率的差异无统计学意义（P〉0．05）。结论CT检查是诊断GIST最重要和有效的方法，仔细分析CT征象对准确判断肿瘤的免疫组化类型有一定的潜在价值。
Objective To evaluate the relationship between CT findings and immunohistochemical types of gastrointestinal stromal tumors （GIST）. Methods CT imaging and clinicopathological data of 85 patients with GIST were analyzed retrospectively. The CT findings of GIST including lesion location, size, contour, boundary, tumor growth pattern, degree of enhancement, necrosis and calcification, were summarized and compared with the immunohistochemical types of the GIST. Results Of the 85 patients, smooth muscle differentiation was in 26 cases （30.6%） , neural differentiation in 20 （23.5%） , both smooth muscle and neural differentiation in 10 （11.8%） and no obvious differentiation in 29 （34.1%） cases. GISTs occurred in the duodenum were more frequently seen in muscle type than in any other types, GIST with smooth muscle differentiation had higher prevalence of huge mass （ larger than 10 cm）, distinctive enhancement and extensive necrosis than other types （ P 〈 0.05 ）. There was no significant difference in the relationships of immunohistochemical types with tumor contour, boundary, growth pattern and calcification among the four groups of GIST （ P 〉 0.05 ）. Conclusions CT scan is the most important and effective method for diagnosis of GIST. Analyzing CT signs has some potential value in judgmet of immunohistochemical types of GIST.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2014年第6期440-445,共6页
Chinese Journal of Oncology
基金
浙江省医药卫生科学研究基金计划（2010KYB116）
关键词
胃肠道间质瘤
体层摄影术
X线计算机
免疫组织化学
诊断
Gastrointestinal stromal tumor
Tomography, X-ray computed
Immunohistochemistry
Diagnosis
