摘要
目的：调查天津市中老年非高血压人群血浆同型半胱氨酸（Hcy）水平及高同型半胱氨酸血症（hHcy, Hcy≥15μmol/L）患病的影响因素。方法采用自然抽样方法，于2011年5月-2012年12月对天津市内六区非高血压居民进行调查，循环酶法检测血浆Hcy，Logistic回归分析hHcy患病的相关因素。结果共入选874例，平均年龄（57＆#177;6）岁，男性25.5%，血浆Hcy水平为12.0μmol/L，hHcy患病为25.2%。多变量Logistic回归分析中，年龄、男性、吸烟、体育锻炼对应的hHcy患病OR（95%CI；P）分别为1.048（1.015-1.083；P=0.004）、4.191（2.359-7.448；P〈0.001）、1.280（0.896-1.829；P=0.175）、0.460（0.259-0.816；P=0.008），蔬菜水果摄入量为250-500 g/d、〉500 g/d与〈250 g/d相比，hHcy患病OR（95%CI；P）分别为0.290（0.179-0.469；P〈0.001）、0.168（0.092-0.309；P〈0.001）。结论男性、年龄是hHcy患病的危险因素，蔬菜水果摄入量、体育锻炼是保护因素。
Objective To investigate the concentration of homocysteine （Hcy） and related factors of hyperhomocyste-inemia （hHcy,Hcy≥15μmol/L） among non-hypertensive people aged between 40-70 in Tianjin. Methods Non-hyperten-sive community residents aged 40-70 years were enrolled randomly from May 2011 to December 2012 in six districts in Tian-jin. Plasma Hcy was assessed by enzyme cycling method. Factors related to hHcy were analyzed in multivariate logistic re-gression models. Results Our study included 874 participants （mean age is 57 ＆#177; 6 years, 25.5%of all are males） and the con-centration of Hcy was 12.0 μmol/L. The OR （odds ratio）（95%CI; P）for hHcy were 1.048（1.015,1.083; P=0.004）, 4.191 （2.359,7.448;P〈0.001）, 1.280（0.896,1.829;P=0.175）, 0.460（0.259,0.816;P=0.008）respectively for age, male, smoking, exercise, and the odd ratio for hHcy were 0.290（0.179, 0.469;P〈0.001）, 0.168（0.092,0.309;P〈0.001）for consumption of vegetable and fruits 250-500 g/d and〉500g/d, compared with〈250 g/d. Conclusion Male and age were adverse factors for hHcy, consumption of vegetable and fruits, and exercise were positive factors.
出处
《天津医药》
CAS
北大核心
2014年第6期613-615,共3页
Tianjin Medical Journal
基金
天津市卫生局科技基金项目(项目编号:11KG133)
