摘要
目的了解住院病人抗凝治疗后静脉血栓栓塞症(venous thromboembolism,VTE)的危险因素,为对其的治疗和预防提供依据。方法收集中国人民解放军总医院2010年2月—2011年6月期间各科室经过系统抗凝治疗的住院患者320名,其中80例为经过系统抗凝治疗后仍发展为VTE的患者,设为病例组。按个体1∶3的配比比例,按年龄(差别小于5岁内)、性别、病种匹配等相同的配比原则,选取同期抗凝治疗后未发生VTE的240例患者设为对照组。应用单因素和多因素Logistic回归模型进行相关危险因素筛查。结果我们发现尽管给予系统的抗凝治疗,颅脑损伤、重症监护以及中心静脉置管三种因素仍为独立危险因素。结论即使给予系统抗凝治疗,颅脑损伤、重症监护、中心静脉置管三种危险因素是住院病人VTE的发生的独立危险因素。临床上提高对这类危险因素的警惕并提前给予抗凝治疗将有助于降低发生VTE的风险。
Objective To analyze the risk factors for VTE of inpatients despite thromboprophylaxis and provide the basis for the treatment and prevention of VTE.Methods We collected 320 cases from PLA general hospital between February 201 0 and June 201 1 .We matched 80 cases who developed in-hospital VTE while taking thromboprophylaxis to 240 controls who did not develop VTE.Matching was done by patient age（difference is less than 5 years old）,sex and disease.We used univariate and multivariate conditional logistic regression to develop a VTE prediction model.Result We identified three independent risk factors for in-hospital VTE despite thromboprophylaxis：craniocerebral trauma,intensive care unit admission and indwelling central venous catheter.Conclusions We identified three risk factors associated with the development of VTE despite thromboprophylaxis in the hospital setting.By recognizing these high risks,clinicians can remain vigilant for signs or symptoms of VTE and help reduce the risk of occurrence of VTE.
出处
《安徽医药》
CAS
2014年第6期1133-1135,共3页
Anhui Medical and Pharmaceutical Journal
