摘要
目的探讨钙粘蛋白E（E-cadherin）编码基因CDH1的基因多态性与我国南方人群非小细胞肺癌（non-small cell lung cancer,NSCLC）进展的关系。方法采用Taqman法检测423例NSCLS病例CDH1基因3个潜在的功能性单核苷酸多态,分别为rs16260C〉A,rs13689T〉C和rs8049282C〉T,用SAS 9.13软件进行非条件Logistic回归,分析上述多态位点与NSCLC进展的关联。结果 rs16260C〉A位点变异与NSCLS进展有显著关联。相较CC基因型携带者,A变异基因型（AC＋AA）携带者初次诊断时是III期和IV期的概率显著上升了145%和206%,后者发生远端转移的概率是前者的1.50倍（OR=1.50,95%CI=[1.00-2.25]）。然而,rs13689T〉C和rs8049282C〉T与NSCLC进展无显著关联。结论 CDH1基因rs16260C〉A遗传变异可显著增加NSCLS患者确诊时为晚期并发生转移的概率,可促进NSCLS的进展。
[Objective] To assess the association between the genetic variants in E-cadherin coding gene CDH1 and progression of non-small cell lung cancer （NSCLC）. [ Methods ] We genotyped putative functional single nn- cleotide polymorphisms （SNPs） of CDH1, those arers16260C〉A, rs13689T〉C and rs8049282C〉T, in 423 cases of NSCLC using the Taqman genotyping assay. The SAS 9.3 softwarewas used to analyzethe effect of the three SNPs genetic variants on lung cancer progression through the multivariate non-conditional logistic regression. [ Results ] The SNP of rs16260C〉A was significantly associated with lung cancer progression. Compared with individuals carry- ing the rs16260CC genotype, those carrying the rs16260A genotypes were more likely to be advanced stages at di- agnosis with a 145% and 206% increased rate for III stage and IV stage. Also, the latter had a significant higher metastasis rate than the former （OR=1.50, 95%CI=1.00-2.25）. However, no such effect was observed for the other SNPs. [ Conclusion] The SNP rs16260C〉A of CDH1 confers a significantly increased rate of being advanced stages and metastasis of NSCLC at diagnosis, which may promote NSCLC progression.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2014年第13期18-22,共5页
China Journal of Modern Medicine
基金
广东省社会发展领域科技计划项目(No:粤科规划2014-137-11/65)
关键词
肺癌
钙粘蛋白E
单核苷酸多态
进展
lung cancer
E-cadherin
single nuclcotide polymorphism
progression
