摘要
目的：观察小牛血去蛋白提取物注射液防治急性放射性口腔黏膜炎的临床疗效。方法：选取2011年3月~2013年10月笔者所在医院病理确诊为鼻咽癌的患者62例,按照随机性原则分为实验组32例,在肿瘤同期放化疗过程中给予静脉滴注小牛血去蛋白提取物注射液,对照组30例,行同期放化疗。两组均予以三维适形放疗/6000~7600cGy/6~8W;同期给予顺铂40mg/m2每周,至放疗结束;最终对两组间黏膜炎损伤分级进行数据汇总比较。结果：两组间急性放射性口腔黏膜炎损伤程度及平均疼痛时间方面差异有统计学意义（P〈0.05）。结论：在对鼻咽癌患者施以放射治疗的同时,给予静脉滴注小牛血去蛋白提取物注射液,可有效减小因同期放化疗所带来的急性放射性口腔黏膜损伤,在一定程度上预防了因患者无法承受同期放化疗而终止治疗的发生率。
Objective： To observe the prevention effect of actovegin in nasopharyngeal carcinoma.Methods 62 cases with nasopharyngeal carcinoma were randomized into two groups：prevention group（32 cases treated with chemoradiotherapy and actovegin） and control group（30 cases treated with chemoradiotherapy） from march 2011 to October 2013 in hospital of the Xinjiang Uyghur Autonomous Region.All patients were received concurrently intravenous infusion of actovegin.Both groups are to be three dimensional conformal radiation therapy/6000-7600cGy/6-8w,at the same time give cisplatin 40 mg/m2 weekly until the end of radiotherapy.End of mucous membrane inflammation injury classification between the groups of data aggregation.The time of occurring acute irradiation mucositis was recorded and it was evaluated according to the protocol proposed by RTOG.The pain degree was estimated using VAS.Results Comparing with the occurring time and the grade of acute irradiation mucositis and the averge pain time between the two groups,there was a significant difference（P＆lt;0.05）,respectively.Conclusion Actovegin has visible effect on prevention acute irradiation mucositis and may postponed the development of acute irradiation mucositis.It can also decrease the degree of mucosal injury,relieve the pain of oropharynx and decrease the probability of extending course of treatment by therapy interruption.
出处
《新疆医学》
2014年第3期6-8,共3页
Xinjiang Medical Journal
