摘要
目的:探讨单次应用胺碘酮对男性患者行急诊体外循环冠状动脉旁路移植术(ONCABG)后新发心房颤动预防的疗效.方法:50例美国麻醉医师协会(ASA)患者全身状况分级III-IV级急诊行ONCABG的男性患者,均伴有高血压和2型糖尿病病史。随机分为试验组(Y组,n=25)和对照组(C组,n=25)。Y组和C组分别在升主动脉开放前经中心静脉注入0.9%氯化钠液20mL和胺碘酮注射液20mL(3mg/kg)。结果:Y组和C组的术后心房颤动发生率(28%vs.24%),胺碘酮转复率(100%vs.100%),差异无统计学意义,但是多元线性回归显示体外循环时间和术后发生心房颤动会影响患者ICU入住时间(P<0.05)。结论:单次静脉预防性应用胺碘酮并不能降低男性患者急诊ONCABG术后心房颤动的发生率;长时间体外循环和术后新发心房颤动是延长患者ICU入住时间的独立危险因素。
Objective：To investigate the effects of intraoperative a single dose of amiodarone on Atrial Fibrillation after emergency on-pump coronary artery bypass grafting （ONCABG） in mail patients. Methods： 50 ASA Ⅲ-Ⅳ（mails）, with hypertension and type 2 diabetes, aged 49-73 undergoing emergency ONCABG were randomly divided into two groups： edaravone group （group Y, n = 25 ）received amiodarone 3mg/kg（20mL） Via central venous before opening the ascending aorta, and control group（ group C, n = 25 ） did not receive amio darone instead of normal saline（20mL）. Results： the incidence of atrial fibrillation（28% vs. 24% ） ,cardiover sion of atrial fibrillation rate （ 100% vs. 100% ）, there were no significant difference in the two groups. But, cardiopulmonary bypass（CPB） time and postoperative atrial fibrillation affects ICU days of patients （ P 〈 0. 05 ） by multiple linear regression analysis. Conclusion ： A single dose of amiodarone can not reduce incidence of atrial fibrillation after emergency ONCABG in mail patients. Longer CPB time and postoperative atrial fibrillation are risk factors for longer ICU days.
出处
《心肺血管病杂志》
CAS
2014年第3期398-401,共4页
Journal of Cardiovascular and Pulmonary Diseases
关键词
体外循环
冠状动脉旁路移植术
心房颤动
胺碘酮
Cardiopulmonary bypass
Coronary artery bypass grafting
Atrial fibrillation
Amiodarone
