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利培酮联合丁螺环酮对精神分裂症阴性症状的疗效 被引量:8

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摘要 目的探讨利培酮联合丁螺环酮治疗精神分裂症阴性症状的效果及安全性。方法选择符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)精神分裂症诊断标准,以阴性症状为主的精神分裂症女性患者60例,采用"不平衡指数最小分配原则"分为利培酮联合丁螺环酮组(研究组)和单用利培酮组(对照组)各30例,疗程12周。于治疗前和治疗后第4、8、12周末采用阳性与阴性症状量表(PANSS)评定疗效,副反应量表(TESS)评定不良反应。结果研究组和对照组有效率分别为93.30%和73.3%,差异有统计学意义(χ2=6.991,P<0.05)。从4周起,研究组PANSS总评分、阴性症状评分及一般精神病理症状评分均低于对照组(P均<0.01)。对照组4例月经失调,研究组无1例发生。结论利培酮联合丁螺环酮可能更有利于改善以阴性症状为主的女性精神分裂症患者的阴性症状,同时可减少或消除单用利培酮所致的性功能障碍。
作者 穆慧 韩翠萍
出处 《四川精神卫生》 2014年第2期164-165,共2页 Sichuan Mental Health
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  • 1张建球,邱述领.帕罗西汀对精神分裂症阴性症状治疗的辅助作用[J].临床精神医学杂志,2004,14(5):296-296. 被引量:34
  • 2张少丽,王冠军.丁螺环酮治疗抑郁症的辅助作用[J].临床精神医学杂志,2007,17(1):62-62. 被引量:5
  • 3Salimi S, Fotouhi A, Ghoreishi A, et al. A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32 (3): 726-732.
  • 4Akhondzadeh S, Malek - Hosseini M, Ghoreishi A, et al. Effect of ritanserin, a 5HT2A/2C antagonist, on negative symptoms of schizophrenia : a double - blind randomized placebo - controlled study. Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32 (8): 1879-1883.
  • 5Amiri A, Noorbala AA, Nejatisafa AA, et al. Efficacy of selegiline add on therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double - blind randomized placebo - controlled study. Hum Psychopharmacol. 2008; 23 (2): 79-86.
  • 6de Lucena D, Fernandes BS, Berk M, et al. Improvement of negative and positive symptoms in treatment -refractory schizophrenia: a double- blind, randomized, placebocontrolled trial with memantine as add - on therapy to clozapine. J Clin Psychiatry, 2009; 70 (10) : 1416 -1423.
  • 7Levkovitz Y, Mendlovich S, Riwkes S, et al. A double - blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early - phase schizophrenia. J Clin Psychiatry, 2010; 71 (2) : 138 -149.
  • 8Freitas C, Fregni F, Pascual- Leone A. Meta-analysis of the effects of repetitive transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia. SchizophrRes. 2009; 108 (1-3): 11-24.
  • 9Cordes J, Falkai P, Guse B, et al. Repetitive transcranial magnetic stimulation for the treatment of negative symptoms in residual schizophrenia: rationale and design of a sham - controlled, randomized multicenter study. Eur Arch Psychiatry Clin Neurosci. 2009; 259 (Suppl 2) : 189 - 197.
  • 10Klingberg S, Wittorf A, Herrlich J, et al. Cognitive behavioural treatment of negative symptoms in schizophrenia patients: study design of the TONES study, feasibility and safety of treatment. Eur Arch Psychiatry Clin Neurosci. 2009; 259 ( Suppl2): 149-154.

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