摘要
目的探讨急性心肌梗死(AMI)患者急诊PCI术后血清组蛋白去乙酰化酶3(HDAC3)、胱抑素C(CysC)和C反应蛋白(CRP)水平的变化及其临床意义。方法 AMI患者42例均接受急诊PCI治疗,所有患者入院时及术后1个月、3个月、6个月、1年检测血清HDAC3、CysC和CRP水平。结果术后定期随访,与入院时比较,42例AMI患者入院时血清HDAC3和CRP水平显著升高(P<0.01),血清CysC水平显著降低(P<0.01)。38例病情稳定患者术后1个月、3个月、6个月、1年血清HDAC3、CysC和CRP水平差异无统计学意义(P>0.05)。4例再发急性冠脉综合征(ACS)患者术后1个月、3个月、6个月血清HDAC3、CysC和CRP水平差异无统计学意义(P>0.05),再发ACS入院时血清HDAC3和CRP水平显著升高(P<0.01),血清CysC水平显著降低(P<0.01)。结论观察AMI患者PCI术后的血清HDAC3、CysC和CRP水平可以间接预测再发ACS的危险。
Objective To investigate the changes and its clinical significance of serum histone deacetylase 3（HDAC3）, cystatin C（CysC） and C-reactive protein（CRP） levels in AMI patients after emergency PCI. Methods 42AMI patients underwent emergency PCI treatment were tested serum HDAC3, CysC and CRP levels at admission and1 month, 3 months, 6 months and 1 year after PCI. Results Compared with tests after PCI, serum HDAC3 and CRP levels in 42 AMI patients hospitalized was significantly higher（P〈0.01）, and serum CysC level was significantly lower（P〈0.01）.（1） In 38 patients with stable disease, there were no significant differences among the serum HDAC3,CysC and CRP levels at 1 month, 3 months, 6 months and 1 year after PCI（P〉0.05）.（2） In 4 patients with recurrent ACS, there were no significant differences among the serum HDAC3, CysC and CRP levels at 1 month, 3 months, 6months and 1 year after PCI（P〉0.05）, while serum HDAC3 and CRP levels were significantly higher（P〈0.01） and serum CysC level was significantly lower in re-admission（P〈0.01）. Conclusion Observation of serum HDAC3, CysC and CRP levels in AMI patients after PCI could indirect the risk of recurrent ACS.
出处
《海南医学》
CAS
2014年第11期1632-1634,共3页
Hainan Medical Journal
基金
陕西省教育厅科研基金(编号:11JK0719)
