摘要
为了增大树形分子的表面官能团密度,降低其结构柔顺性,以三(2-氨基乙基)胺为原料合成了一种新核树形分子.通过与丙烯酸甲酯在避光条件下的迈克尔加成反应得到末端为酯基的0.5代树形分子,将得到的产物与乙二胺进行酰胺化反应制得末端为氨基的1.0代树形分子.重复以上两个反应,合成得到1.0代到4.0代以三(2-氨基乙基)胺为核的聚酰胺胺树形分子.反应过程中,运用薄层层析色谱检验以及观察红外光谱中酯基峰的消失与出现判断反应程度.每一步得到的粗产品采用柱层析分离的方法和乙醚沉降法进行分离提纯,并通过红外光谱和核磁共振氢谱对所得化合物的分子结构进行表征,证明了所得化合物即为目标化合物.三(2-氨基乙基)胺的引入使得所合成的树形分子具有较小的核单元.
To enlarge end-group density and decrease molecular flexibility,tris（2-aminoethyl）amine was used for the synthesis of new core dendrimers.Ester-terminating 0.5 generation polyamidoamine dendrimers with a tris（2 aminoethyl）amine core were synthesized through Michael addition using methyl acrylate as reactant in the dark,then they were used as reactant to synthesize amino-terminating 1.0 generation polyamidoamine dendrimers by amidation reaction; finally,generation 1.0 to generation 4.0 polyamidoamine dendrimers with a tris（2-aminoethyl）amine core were synthesized through iterative reactions.The extent of reactions was estimated through layer chromatograph and the ester peak was observed in fourier transform infrared spectra.The raw products were purified using column chromatography and sedimentation process.Fourier transform infrared and 1H nuclear magnitic resonance spectra were used for characterization.The core units of dendrimers decrease by introducing tris（2 aminoethyl） amine.
出处
《武汉工程大学学报》
CAS
2014年第4期45-49,共5页
Journal of Wuhan Institute of Technology
基金
国家自然科学基金(51003081)
