摘要
目的：观察柔肝熄风汤对中风先兆证患者的干预作用.方法：将符合纳入标准的50例患者随机分为两组,每组25例.治疗组予自拟方柔肝熄风汤口服,对照组予阿司匹林肠溶片、辛伐他汀片.两组连续干预8周.结果：在临床疗效方面,治疗组总有效率为92.00％（95％ CI=73.95％～99.05％）,对照组为64.00％ （95％ CI =45.18％～ 82.82％）,两组综合疗效比较（u=1.783 2,P=0.074 7）,差异接近临界状态;且治疗组在改善患者部分症候方面优于对照组（P＜0.05）.在预防中风发生方面,经半年随访,治疗组发生中风0例,对照组发生2例.结论：柔肝熄风汤对中风先兆证患者的治疗作用优于阿司匹林肠溶片、辛伐他汀片的证据尚不够充分,尽管其收益为OR =0.15 （95％ CI =0.03～0.81）,NNT=4 （95％CI=1.96～19.84）;预防作用揭示,治疗组每治疗12.5例患者,可较对照组减少1例中风患者的发生（尽管其OR不具比较意义,无法比较;NNT=12.5,其95％CI理论值=5.30 ～47.47）,这可能就是该方“治未病”的价值.
Objective ： To observe the prevention of rougan xifeng decoction on patients with threatened apoplexy. Methods： 50 patients met the criteria were randomly divided into two groups, 25 cases in each group. The treatment group was traeted with self-dispened rougan xifeng decoction, while the control group with Aspirin enteric - coated tablets and simvastatin tablets. Two groups were treated continuously for 8 weeks. Results ： In clinical efficacy, the total effective rate of treatment group was 92.00% （95% CI = 73.95% - 99.05% ）, of control group 64.00% （95% CI = 45. 18% - 82. 82% ）, compared the integrated effect of two groups （ u = 1. 783 2, P = 0. 074 7 ）, the differences close to the critical state ; and in partial symptoms improvement of patients the treatment group was better than the control group （P 〈 0.05 ）. In the prevention of apoplexy and after six months of followup, the treatment group had a apoplexy of 0 cases, while the control group occurred 2 cases. Conclusion： the evidence, that the therapeutic effect of liver-easing and endogenous wind-calming decoction on patients with apoplexy symptoms is better than Aspirin enteric-coated tablets and simvastatin tablets, is still insufficient, despite its benefit was OR =0.15 （95% CI = 0.03 -0.81 ）, NNT =4 （95% CI = 1.96 - 19.84） ;the preventive effect reveals, the treatment per 12.5 cases patients in treatment group may reduce the incidence of one case of apoplexy patients than the control group （despite its OR has non-comparative significance, and can not be compared ;NNT = 12.5, its CI theoretical value of 95 % =5.30 -47.47 ）, This may be the value of＇ prenventive traement of disease＇ of the prescription.
出处
《山西中医》
2014年第6期37-38,41,共3页
Shanxi Journal of Traditional Chinese Medicine
