摘要
目的评价帕瑞昔布行超前镇痛在骨科手术中的疗效。方法利用计算机检索考克兰图书馆、西文生物医学期刊文献数据库、美国国立医学图书馆生物医学信息检索系统、荷兰医学文摘、中国生物医学文献数据库、万方数据库、维普中文科技期刊全文数据库、中国学术期刊全文数据库,手工检索相关杂志并追检纳入文献的参考文献。检索时间为1993年1月—2013年1月,检索关键词为"帕瑞昔布、超前镇痛、骨科手术"。对纳入的文献均由2位评价员单独评价其质量,使用SPSS 17.0和Review manager 5.0软件对符合质量标准的随机对照试验(RCTs)行系统评价。结果共纳入7篇符合标准的RCT,其中治疗组248例(使用帕瑞昔布),对照组249例(使用芬太尼和罗哌卡因),均比较了患者术后24及48 h的视觉模拟评分法(VAS)评分。系统评价结果显示:相比芬太尼及罗哌卡因,帕瑞昔布均可显著降低骨科术后24及48 h的VAS评分,缓解患者的疼痛程度。结论帕瑞昔布行超前镇痛在骨科手术中的疗效显著。
[Objective]To evaluate the effectiveness of preemptive analgesia with parecoxib in orthopedic surgery.[Methods]The Cochrane Library,EMCC,PubMED,EMBase,CBM,Wanfang Data,CQVIP and CJFD were searched by computer,and manual retrieval was applied to search the relevant journals and references.The retrieval time was between January 1993 and January 2013,and the key words included parecoxib,preemptive analgesia and orthopedic surgery.All included literatures were evaluated by two evaluators respectively,and the randomized controlled trials（RCTs） that met the quality standards were evaluated by SPSS 17.0and Review manager 5.0.[Results]A total of 7 RCTs on this topic were included under the standard,with 248 cases in the treatment group（parecoxib） and 249 cases in the control group（fentanyl and ropivacaine）,and the scores of visual analogue scales（VAS） in 24 hours and 48 hours after operation were compared in all RCTs.The system evaluation results showed that parecoxib significantly reduced VAS scores in 24 hours and 48 hours after orthopedic operation as compared with those of fentanyl and ropivacaine,and relieved the patient＇s pain level.[Conclusion]The preemptive analgesia with parecoxib has significant effect in orthopedic surgery.
出处
《职业与健康》
CAS
2014年第12期1644-1648,共5页
Occupation and Health
关键词
帕瑞昔布
超前镇痛
骨科手术
Parecoxib
Preemptive analgesia
Orthopedic surgery
