摘要
通过溶液静电纺丝的方法,将水溶性药物二氯乙酸钠(DCA)包裹入油溶性聚乳酸(PLA)中,制备出二氯乙酸钠电纺纤维毡。将其应用于宫颈癌的活体实验中,结果表明在为期19 d的治疗下,荷瘤小鼠的肿瘤抑制率达到94%,总体康复率达到38%。同时,DCA电纺纤维毡还极大地抑制了宫颈癌后期复发和转移的趋势,提高了荷瘤小鼠的生存质量,是一种安全且疗效确切的抗癌给药剂型。
Solidum dichloroacetate(DCA) loaded electrospun mats was fabricated through the solution electrospun method.When applying this DCA-loaded electrospun mats on the therapy of the subcutaneous cervical cancer model,a 94% tumor suppression rate and an overall 38% recovery rate were achieved after 19 days' treatment.The trend of recurrence and metastasis was also significantly inhabited.Meanwhile,DCA-loaded electropsun mats improved the life quality of tumor-bearing mice fundamentally.Therefore,DCA administrated by electrospun mats is a safe approach for the treatment of anti-cervical cancer.
出处
《应用化学》
CAS
CSCD
北大核心
2014年第7期763-769,共7页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金(51273194
51021003
50733003
21174143)
吉林省科技厅项目(20100588)资助~~
关键词
宫颈癌
二氯乙酸钠
静电纺丝
生存质量
cervical cancer
sodium dichloroacetate
electropsun mats
suvivial quality