摘要
目的：研究三七总皂苷中人参皂苷Rg1在肠道的吸收特征,为剂型设计、开发提供科学依据。方法：运用大鼠在体肠吸收模型,采用在体循环灌流法、高效液相色谱法、紫外分光光度法研究pH值、药物浓度以及不同肠段对三七总皂苷中人参皂苷Rg1吸收的影响。结果：循环液的pH值对三七总皂苷中人参皂苷Rg1的小肠吸收无显著影响;0.264～0.974 mg·ml-1范围内三七总皂苷中人参皂苷Rg1的吸收量与药物浓度呈良好线性关系;不同小肠部位三七总皂苷中人参皂苷Rg1的吸收速率大小顺序为：十二指肠＞空肠=回肠。结论：三七总皂苷中人参皂苷Rg1的吸收过程为被动扩散过程,其在大鼠肠道内无特定吸收部位;提示可将三七总皂苷设计成缓释、迟释系统,有助于提高患者的顺应性和药物的生物利用度。
OBJECTIVE To study the characteristics of ginsenoside Rg1in PNS absorbed in the rat intestine,and to provide scientific basis for dosage form design and exploitation.METHODS The rat intestine absorption model and non-vitro recirculating perfusion,HPLC,UV spectrophotometry were used to study the effects of pH values,drug concentration and the different intestinal segments on absorption of ginsenoside Rg1.RESULTS Circulating fluid pH had no significant effect on the intestinal absorption of ginsenoside Rg1in PNS;at the range of 0.264-0.974 mg·ml-1,the absorption of ginsenosides Rg1in PNS showed a good linear relationship with drug concentration.The order of different parts of the small intestine＇s absorption rate for ginsenoside Rg1 in PNS was as follows：duodenum〉jejunum=ileum.CONCLUSION The absorption process of ginsenoside Rg1in PNS is a passive diffusion process,there is no specific absorption site for ginsenoside Rg1in rat intestine;PNS can be designed into a slow-release,delayed-release system to improve the patient compliance and drug bioavailability.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第12期998-1001,1023,共5页
Chinese Journal of Hospital Pharmacy
关键词
人参皂苷RG1
在体循环灌流法
吸收部位
ginsenoside Rg1
non-vitro recirculating perfusion
absorption site
