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血小板活化的分子标志物的探讨及在疾病中意义 被引量：7

Discussion of Plasma Marker of Platelet Activation and Clinical Significance
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摘要 在正常情况下循环血液中,血小板处于静息状态,而在某些生理状态或病理状态下,血小板可被激活后活化。近些年来,通过对血小板活化的深入研究,发现很多血小板活化后释放的因子在血小板活化中发挥着的重要作用。血小板活化的因子包括α颗粒内容物,如β球蛋白和血小板因子4等,以及血小板膜蛋白或其水解片段,如P-选择素、糖萼蛋白、糖蛋白V等。这些标志物可用ELISE方法在体外测得以反映血小板的活化状态。
作者 何娟 闫荣 戴克胜 方琪
机构地区 苏州大学附属第一医院神经内科 江苏省血液研究所血栓室
出处 《血栓与止血学》 2014年第4期207-208,共2页 Chinese Journal of Thrombosis and Hemostasis
关键词 血小板活化 分子标志物 α颗粒 血小板糖蛋白临床疾病
分类号 R331.143 [医药卫生—人体生理学]
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参考文献6

二级参考文献31

  • 1陈秋月,丁美萍,金笑平,林仙方,陈葆国.血小板活化与脑梗死及颈动脉粥样硬化的相关性[J].中国动脉硬化杂志,2004,12(6):704-706. 被引量：6
  • 2马莉,汪中强,吴蔚,顾健.流式细胞术检测脑梗死患者的血小板活化[J].血栓与止血学,2005,11(5):211-212. 被引量：5
  • 3[1]Gruff J,Klinkhardt U,Schini-Kerth VB,et al. Close relationship between the platelet activation marker CD 62p and the granular release of platelet derived factor[ J ]. Journal of Pharmacology & Experimental Therapeutics,2002,300(3) :95 ～97.
  • 4[2]Baglia FA,Badellino KO,Li CQ,et al. Factor Ⅺ binding to the platelet glycoprotein Ib-Ⅸ-Ⅴ complex promotes factor Ⅺ activation by thrombin[J]. Journal of Biological Chemistry,2002,277(3) :1662 ～1668.
  • 5[3]Gurney D, Lip GY, Blann AD. A reliable plasma marker of platelet activation: does it exit [ J ] ?, American Journal of Hematology, 2002,70(2) :139 ～ 144.
  • 6[4]Kurata Y, Hayashi S, Kiyoi T, et al. Diagnostic value of tests for reticulated platelets, plasma glycocalicin, and thrombopoietin lelevels for disceiminating between hyperdestructive and hypoplastic thrombocytopenia[ J ]. American Journal of Clinical Pathology, 2001, 115 ( 5 ):656 ～ 664.
  • 7[5]Ramakrishnan V, DeGuzman F, Bao M, et al. A thrombin receptor function for platelet glycoprotein Ib-Ⅸ unmasked by cleavage of glycoprotein Ⅴ [J]. Pro Nat Aca Sci USA,2001,98(4) :1823 ～1828.
  • 8[6]Ni H, Ramakrishnan V, Ruggeri ZM, et al. Increased thrombogenesis and embolus formation in mice lacking glycoprotein Ⅴ [ J ]. Blood,2001,98(2) :368 ～373.
  • 9[7]Ravanat C,Freund M, Mangin P, et al. GP V is a marker of in vivo platelet activation study in a rat thrombosis mode[ J]. Thromb Haemost,2000 ,83 :327 ～ 333.
  • 10[8]Blann AD, Lanza F, Galajda P, et al. Increased platelet glycoprotein Ⅴ levels in patients with coronary and peripheral atherosclerosis[ J].Thromb Haemost,2001,86:777 ～783.

共引文献31

同被引文献72

  • 1韩雅玲,王守力,李毅,荆全民,马颖艳,王祖禄,王冬梅,栾波,王效增.急性冠状动脉综合征患者冠状动脉支架术前高负荷量氯吡格雷预治疗近期疗效[J].中国介入心脏病学杂志,2005,13(1):9-12. 被引量：53
  • 2刘嵘,魏文宁.应用激光扫描共聚焦显微术观察血小板活化及其形态改变[J].血栓与止血学,2006,12(5):197-200. 被引量：2
  • 3张建维,贾三庆,曹树军,王雷.不同负荷量的氯吡格雷对急性冠脉综合征患者血小板聚集功能及氯吡格雷抵抗发生率的影响[J].实用医学杂志,2007,23(21):3359-3360. 被引量：12
  • 4Ellis WC, Cassidy LK, Finney AS, et al. Thrombelasto- graph(TEG) analysis of platelet gel formed with different thrombin concentrations [J]. J Extra Corpor Technol, 2005,37 (1) :52-57.
  • 5Guthikonda S, Lev EI, Kleiman NS. Resistance to anti- ptatelet therapy[J]. Curt Cardiol Rep, 2005,7 (3) : 242- 248.
  • 6Angiolillo DJ, Shoemaker SB, Desai B, et al. Randomized comparison of a high clopidogrel maintenance dose in pa- tients with diabetesmellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabe- tes Mellitus (OPTIMUS) study [J]. Circulation, 2007, 115(6) : 708-716.
  • 7Alstrom U,Tyden H,Oldgren J, et al. The platelet inhibi- ting effect of a clopidogrel bolus dose in patients on long- term acetylsalicylic acid treatment [J]. Thromb Res, 2007,120(3) :353-359.
  • 8Craft RM, Chavez J J, Bresee SJ, et al. A novel modifica- tion of the Thrombelastograph assay,isolating platelet function, correlates with optical platelet aggregation[J]. J Lab Clin Med,2004,143(5) :301-309.
  • 9Dropinski J,Jakiela B, Sanak M, et al. The additive anti- platelet action of clopidogrel in patients with coronary ar- tery disease treated with aspirin[J]. Thromb Haemost, 2007,98(1) : 201-209.
  • 10Sbrana S, Della Pina F, Rizza A, et al. Relationships be- tween optical aggregometry(type born) and flow cytome- try in evaluating ADP-induced platelet activation[J]. Cy-tometry B Clin Cytom,2008,74(1) :30-39.

引证文献7

二级引证文献38

血栓与止血学
2014年 第4期

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