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伴躯体症状抑郁症患者皮质醇与述情障碍的相关性 被引量:13

Relationship between the levels of serum cortisol and alexithymia in depressive patients with somatic symptoms
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摘要 目的 探讨伴躯体症状的抑郁症患者血清皮质醇水平与述情障碍程度的相关性.方法 采用放射免疫法测定30例伴躯体症状的抑郁症患者(躯体组)及30例不伴躯体症状的抑郁症患者(不伴组)晨起血清皮质醇水平,使用述情障碍量表(TAS-20)评定两组患者述情障碍.结果 (1)躯体组血清皮质醇水平显著高于不伴组[(533.88± 144.10) μmol/L vs (458.27±82.87) μmol/L,P<0.01],差异有统计学意义.(2)躯体组述情障碍总分及识别情感障碍、描述情感障碍因子分高于不伴组[(67.13±6.96)分vs(62.03±7.14)分,(24.50±3.78)分vs (21.63±3.63)分,(15.30±2.69)分vs(13.57±2.03)分,均P<0.01],差异有统计学意义.(3)躯体组血清皮质醇水平与述情障碍总分正相关(r=0.596,P<0.01),与识别情感障碍、描述情感障碍、外向性思维因子分正相关(r=0.391,0.435,0.452,均P<0.05).(4)不伴组血清皮质醇水平与述情障碍总分正相关(r=0.418,P<0.05),与外向性思维因子分正相关(r=0.489,P<0.01).结论 伴躯体症状较不伴躯体症状的抑郁症患者存在较重的述情障碍,具体体现在识别情绪障碍、描述情绪障碍.述情障碍的严重程度与血清皮质醇水平存在正相关关系. Objective To investigate the correlation between the level of serum cortisol and alexithymia in depressive patients with somatic symptoms.Methods The morning level of serum cortisol was measured with radioimmunoassay in 30 depressive patients with somatic symptoms (somatization group) and 30 depressive patients without somatic symptoms (non-somatization group).The severity of alexithymia was evaluated with Toronto alexithymia Scale(TAS-20).Results (1) The level of serum cortisol in somatization group was significantly higher than that in non-somatization group((533.88±144.10) μmol/L vs (458.27±82.87) μmol/L,P〈0.01).(2) The total TAS score and the factor score of “Difficulty in identifying feelings” and “Difficulty in describing feelings” in somatization group were obviously higher than those in non-somatization group,respectively ((67.13 ± 6.96) vs (62.03±7.14),(24.50±3.78) vs (21.63±3.63),(15.30±2.69) vs (13.57±2.03),all P〈0.01).(3) The level of serum cortisol in somatization group was positively correlated with the total score of alexithymia (r=0.596,P〈0.01) and the factor score of “Difficulty in identifying feelings”,“ Difficulty in describing feelings”,“ externally oriented thinking”,respectively (r=0.391,0.435,0.452,all P〈0.05).(4) The level of serum cortisol in non-somatization group was positively related to the total TAS score (r=0.418,P〈0.05) and the factor score of “externally oriented thinking”(r=0.489,P〈0.01).Conclusions Compared with depressive patients without somatic symptoms,depressive patients with somatic symptoms had more severe alexithymia,especially in “Difficulty in identifying feelings” and “Difficulty in describing feelings”.The severity of alexithymia was positively correlated with the level of serum cortisol.
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2014年第6期511-513,共3页 Chinese Journal of Behavioral Medicine and Brain Science
关键词 抑郁症 躯体症状 血清皮质醇 述情障碍 Depression Somatic symptoms Cortisol Alexithymia
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参考文献15

  • 1Zunhammer M,Eberle H,Eichhammer P,et al.Somatic symptoms evoked by exam stress in university students:the role of alexithymia,neuroticism,anxiety and depression[J] .PLoS One,2013,8 (12):e84911.
  • 2Bohman H,Jonsson U,P(a)(a)ren A,et al.Prognostic significance of functional somatic symptoms in adolescence:a 15-year community-based follow-up study of adolescents with depression[J] .BMC Psychiatry,2012,12:90.
  • 3徐阿红,吴爱勤.抑郁症躯体症状的研究进展[J].神经疾病与精神卫生,2009(4):354-356. 被引量:6
  • 4凌宇,钟明天,蚁金瑶,杨娟,姚树桥.述情障碍特征对青少年应激与抑郁症状的调节作用[J].中国临床心理学杂志,2012,20(2):168-171. 被引量:23
  • 5Taylor GJ,Bagby RM.Psychoanalysis and empirical research:the example of alexithymia[J] .J Am Psychoanal Assoc,2013,61 (1):99-133.
  • 6Kojima M,Senda Y,Nagaya T,et al.Alexithymia,depression and social support among Japanese workers[J] .Psychother Psychosom,2003,72(6):307-314.
  • 7寻知元,杨建立,陈玉辉,田红军,毛富强.重度抑郁患者血浆催产素、皮质醇水平与抑郁严重程度关系的初步研究[J].中华行为医学与脑科学杂志,2012,21(2):152-154. 被引量:9
  • 8Howren MB,Lamkin DM,Suls J.Associations of depression with C-reactive protein,IL-1,and IL-6:a meta-analysis[J] .Psychosom Med,2009,71 (2):171-186.
  • 9Thomas N,David A,Holder-Perkins V.Painful physical symptoms in depression:a clinical challenge[J] .Pain Med,2007,8 (Suppl 2):s75-82.
  • 10Goodin BR,Quinn NB,King CD,et al.Salivary cortisol and soluble tumor necrosis factor-α receptor Ⅱ responses to multiple experimental modalities of acute pain[J] .Psychophysiology,2012,49 (1):118-127.

二级参考文献49

  • 1许毅,蔡巍,胡健波,石其昌,李鲁.文化程度及生活地域对常见精神疾病知晓率及就医方式的影响[J].中华预防医学杂志,2005,39(4):237-240. 被引量:25
  • 2张付全,唐秋萍,刘破资.述情障碍与躯体化[J].国际精神病学杂志,2005,32(3):184-186. 被引量:26
  • 3林实,赵士芳,闫福华.应激中述情障碍对唾液SIgA及Cor的影响[J].上海口腔医学,2005,14(6):561-564. 被引量:6
  • 4Kirmayer LJ, Robbins JM, Dworkind M, et al. Somatization and the recognition of depression and anxiety in primary care [J]. AmJ Psychiatry,1993,150(5):734.
  • 5Cheung FM. Psychological symptoms among Chinese in urban Hong Kong[J]. Social Science &Medicine, 1982,16( 14 ) : 1 339 - 1 344.
  • 6Gulec H ,Sayar K ,Ozkorumak E. Somatic symptoms of depression[J]. Turk Psikiyat ri Derg, 2005,16 ( 2 ) : 90- 96.
  • 7Honkalampi K, Hintikka J, Tanskanen A, et al. Depression is strongly associated with alexithymia in the general population[J]. J Psychosomatic Res,2000,48( 1 ) : 99- 104.
  • 8Bodini B, Mandarelli G, Tomassini V, et al. Alexithymia in multiple sclerosis: relationship with fatigue and depression[J]. Acta Neurologiea Seandinavica, 2008,118 ( 1 ) : 18- 23.
  • 9De Guchl V, Heiser W. Alexithymia and somatization: quantitative review of the literature[J].J Psychosomatic Res,2003, 51(5) :425-434.
  • 10Sayar K, Kirmayer LJ, Taillefer SS. Predictors of symptoms in depressive disorder[J]. General Hospital Psychiatry,2003, 25(2) :108-114.

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