摘要
目的:研究不同临床类型的口腔扁平苔藓(OLP)中细胞信号传导和转录激活因子3(STAT3)的表达及意义。方法:采用免疫组织化学方法分别检测10例正常口腔黏膜组织,29例非糜烂型OLP、16例充血糜烂型OLP损害中STAT3的表达。结果:STAT3阳性表达分布于细胞质和细胞核内。正常口腔黏膜、非糜烂型OLP、糜烂型OLP上皮层中STAT3阳性表达率分别为30.00%(3/10)、75.86%(22/29)、93.75%(15/16);固有层中分别为0%(0/10)、65.52%(19/29)、100.00%(16/16);三种类型上皮层两两之间相比,差异有统计学意义(P<0.05);固有层两两之间相比,只有非糜烂型OLP和糜烂型OLP之间差异没有统计学意义(P>0.05)。结论:STAT3与OLP上皮层的炎症进程密切相关,对STAT3表达的研究将有助于进一步探究OLP的发病机制和早期临床诊疗。
Objective：To study the expression and significance of STAT3 in Oral Lichen Planus （OLP） of different clinical types. Method：The immunohistochemical assay was used to detect 10 cases of normal oral mucosa,30 patients with non-erosive OLP and 20 patients with erosive OLP of STAT3 protein expression in the lesions. Result：STAT3 was expressed in the cell cytoplasm,and nuclear expression was also found in some cells in OLP.In the cases of normal oral mucosa,non-erosive and erosive OLP,the rate of STAT3 expression in epithelial layer was 30 %（3/10）、75.86 %（22/29）、93.75 %（15/16）,respectively;in lamina propria,0 %（0/10）、65.52 %（19/29）、100 %（16/16）,respectively;There were statis-tical significances of STAT3 expression between normal oral mucosa and non-erosive OLP as well as erosive OLP in epithe-lial layer （P〈0.05）,while no statistical significances of STAT3 expression were found only between non-erosive and erosive OLP in lamina propria （P 〉0.05）. Conclusion：The over-expression of STAT3 played an important role in the inflammation progression of the OLP＇s epithelium,and the study of STAT3 expression was useful for detection of the pathogenesis and early diagnosis of OLP.
出处
《临床口腔医学杂志》
2014年第6期323-326,共4页
Journal of Clinical Stomatology
基金
国家自然科学基金(81170967)
2013~2014国家临床重点专科建设项目资助(国卫办医函[2013]544号)
