摘要
目的:探讨血浆同型半胱氨酸( Hcy)水平与脑小血管病( SVD)的相关性。方法回顾性分析218例脑SVD患者的临床资料,并根据诊断将其分为无症状脑梗死组(SBI,56例),脑白质疏松组(LA,143例),颅外段动脉硬化组( EC,28例),颅内段动脉硬化组( IC,31例)。测定所有患者的血浆Hcy水平,分析其对脑SVD发病的影响。结果脑SVD患者以老年女性居多,高血压、糖尿病比例高,且尿酸、Hcy、CRP 水平也普遍升高。单因素logistic分析显示,血浆Hcy均是SBI、LA、EC、IC发生的危险因素,而多因素logistic回归分析显示,血浆Hcy是SBI(OR:3.47,95%CI:1.76~4.65)、LA(OR:2.98,95%CI:1.48~5.64)的独立危险因素( P<0.05),而血浆Hcy与EC、IC无明显相关性( P>0.05)。 LA患者中随着Fazekas分级的增加,血浆Hcy水平依次升高( P<0.05)。结论血浆Hcy与脑SVD,尤其是SBI、LA具有相关性,是脑SVD发病的独立危险因素,但与脑大血管病变( EC、IC)之间的关系不明显。
Objective To explore the relationship between plasma homocysteine ( Hcy) and cerebral small vessel disease (SVD).Methods Clinical data on 218 patients with cerebral SVD was retrospectively analyzed , and all the cases were divided into SBI group (n=56), cWMH group(n=143), EC group(n=28), IC group(n=31) according to the diagnosis .Plasma Hcy was determined to analyze its impact on cerebral SVD .Results Cerebral SVD had a higher prevalence of old age , female gender , hypertension , DM, and had higher values for uric acid , Hcy, CRP than those without SVD .Univariate logistic analysis showed that plasma Hcy was risk factors for SBI , LA, EC, IC (P0.05).With the increase of Fazekas ’ grade, plasma Hcy levels increase in turn among LA patients (P〈0.05).Conclusion Plasma Hcy is correlated with cerebral SVD , especially SBI, LA, is an independent risk factors of cerebral SVD , but not found to be obviously associated with cerebral large vessel disease such as EC, IC.
出处
《脑与神经疾病杂志》
2014年第3期196-199,共4页
Journal of Brain and Nervous Diseases
基金
上海市卫生局青年科研基金项目(20134Y099)
关键词
脑小血管病
同型半胱氨酸
无症状脑梗死
脑白质疏松
Cerebral small vessel disease
Homocysteine
Silent brain infarction
Cerebral white matter hyperintensity