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妊娠早期游离甲状腺素正常妇女甲状腺自身抗体阳性对甲状腺疾病及妊娠结局的影响 被引量:7

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摘要 组[21.9%(14/64)与6.5%(32/495),RR=4.2,95%CI:2.1~8.3,χ^2=17.82,P〈0.01],亚临床甲状腺功能减退症的发生率也明显升高[18.8%(12/64)与4.9%(24/495),RR=4.6,95%CI:2.2~9.8,χ^2=18.18,P〈0.01]。TPOAb阳性组中有18例TPOAb≥500 U/L,亚临床甲状腺功能减退症的发生率为38.9%(7/18),明显高于TPOAb阳性但〈500 U/L者[10.9%(5/46)](RR=4.4,95%CI:1.1~17.0,χ^2=4.73,P〈0.05)。TPOAb阳性组孕妇妊娠早期自然流产发生率显著高于阴性组[10.9%(7/64)与2.2%(11/495),RR=5.5,95%CI:2.1~14.8,χ^2=13.81,P〈0.01]。结论妊娠早期TPOAb阳性对妊娠结局有不利影响,妊娠早期应重视TPOAb的筛查。
出处 《中华围产医学杂志》 CAS 北大核心 2014年第6期414-418,共5页 Chinese Journal of Perinatal Medicine
基金 卫生行业科研专项项目(200802008) 辽宁省科学技术计划项目(2007225010)
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同被引文献48

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