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老年高血压病患者血清瘦素水平及其与颈动脉内膜中层厚度的相关性研究

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摘要 目的探讨老年高血压病患者血清瘦素(Lep)水平及其与颈动脉内膜中层厚度(IMT)的相关性。方法选取老年高血压病患者166例,设为高血压组;另于同期选取老年健康志愿者60例,设为对照组。检测两组受试者的体质量指数(BMI)、腰臀比(WHR)等一般指标、血脂生化及血清Lep,超声检测IMT。结果两组BMI、WHR及血脂指标差异均无统计学意义(均>0.05);高血压组血清Lep及IMT均高于对照组(均<0.05)。经超声检测,动脉粥样硬化(AS)组血清Lep水平高于非AS组水平(<0.05)。偏相关分析显示,颈动脉IMT与患者年龄、WHR、Lep呈正相关(均<0.01)。结论 Lep可能参与了AS的发生发展过程,为阐明及干预高血压病患者AS的发生提供了新的思路。
机构地区 青田县中医医院
出处 《现代实用医学》 2014年第6期737-738,共2页 Modern Practical Medicine
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