注射绒毛膜促性腺激素日性激素水平对多囊卵巢综合征患者体外受精—胚胎移植临床妊娠率的影响被引量：3

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摘要目的:探讨注射绒毛膜促性腺激素(HCG)日性激素水平对多囊卵巢综合征(PCOS)患者体外受精—胚胎移植(IVF-ET)临床妊娠率的影响。方法:对75例PCOS患者应用GnRH拮抗剂方案施行IVF-ET,在注射HCG日应用化学免疫发光法测定性激素雌二醇(E2)、黄体生成素(LH)、孕酮(P)水平。比较妊娠组与非妊娠组的HCG日血清LH水平;按HCG日的血清P水平不同分为2组:A组:血清P≤2.86nmol/L;B组:2.86nmol/L<P≤4.77nmol/L;比较血清P与临床妊娠率的关系;将HCG日E2(每卵子)按每256.9pmol/L分为4组:组1:血清E2(每卵子)≤513.8pmol/L;组2:513.8pmol/L<E2(每卵子)≤770.7pmol/L;组3:770.7pmol/L<E2(每卵子)≤1 027.6pmol/L;组4:E2(每卵子)>1 027.6pmol/L。比较E2(每卵子)水平与临床妊娠率的关系。结果:LH得到很好抑制,无一例出现LH峰,妊娠组与非妊娠组的血清LH水平无明显差异(P>0.05);A组临床妊娠率高于B组(P<0.05);E2(每卵子)各组比较,组2临床妊娠率最高,其次是组3;组2,组3临床妊娠率均高于组4,差异有统计学意义(P<0.05);组2与组3临床妊娠率比较无统计学差异(P>0.05)。结论:GnRH拮抗剂方案能有效地抑制PCOS患者体内的LH,对PCOS患者行IVF-ET是一种比较理想的选择;注射HCG日的血清P水平和E2(每卵子)水平是预测临床妊娠率比较好的指标;HCG日的LH水平不能预测IVF-ET的临床妊娠率。

作者谭秀群

机构地区广西医科大学第三附属医院医学生殖中心

出处《广西医科大学学报》 CAS 2014年第3期459-462,共4页 Journal of Guangxi Medical University

基金广西南宁市科技攻关与新产品试制资助项目(No.201106045C) 广西壮族自治区卫生厅自筹经费科研项目(No.Z2011152)

关键词多囊卵巢综合征 GNRH拮抗剂体外受精 — 胚胎移植

分类号 R711.75 [医药卫生—妇产科学]

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参考文献5

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