摘要
目的探讨膀胱尿路上皮癌中Livin蛋白的表达情况及其临床意义。方法应用免疫组化Super Vision(SV)两步法检测Livin蛋白在86例膀胱尿路上皮癌组织(A)及其癌旁非癌组织(B)和20例正常膀胱黏膜组织(C)中的表达情况,并分析其与膀胱尿路上皮癌临床病理特征的关系。结果 Livin蛋白在ABC中的阳性表达率分别为67.4%(58/86),3.5%(3/86),0(0/20),AB和AC均有统计学差异(P<0.01),BC无统计学差异(P>0.05);Livin蛋白与膀胱尿路上皮癌是否复发相关(P<0.05),而与性别、年龄、肿瘤数目、组织学分级、临床病理分期、淋巴结转移与否等无关(P>0.05)。结论 Livin可能在某些环节参与了膀胱尿路上皮癌的发生及复发,有望成为膀胱尿路上皮癌早期诊断、监测复发的瘤标之一。
Objective To investigate the expression of Livin protein in urothelial carcinoma of the bladder and its clinical significance. Methods The expression of Livin protein was assessed in 86 cases with urothelial carcinoma of the bladder tissues （A）, their peritumorial non-cancerous tissues （B） and 20 cases of normal bladder mucosa tissues （C） by Super Vision （SV） immunohistochemical method, and its relationship with clinicopathological characteristics was ana- lyzed. Results The expression of Livin protein in ABC were 67. 4% （58/86） ,3. 5% （3/86） and 0. 0% （0/20）. Significant differences of expression of Livin protein were found between A and B, A and C （P〈0. 01）, while not found between B and C （P〉0. 05）. The expression of Livin protein was significantly correlated with recurrence （P〈0. 05） and not correla- ted with sexualities, ages, the number of tumors, histological grades, clinicopathological stages and lymph node metastasis or not et al （P〉0.05）. Conclusion Livin may be involved in the occurrence and recurrence of urothelial carcinoma of the bladder in some areas. And it is expected to become a tumor marker for early diagnosis and recurrence monitoring of urothelial carcinoma of the bladder.
出处
《华南国防医学杂志》
CAS
2014年第5期445-448,共4页
Military Medical Journal of South China
