摘要
目的探讨自体骨髓间充质神经干细胞移植治疗脑梗死的疗效及安全性。方法选取2010年12月至2012年12月在我院治疗的脑梗死患者58例，采用随机数字表法分为对照组和移植组，每组29例。2组患者均给予常规药物治疗及康复干预；移植组在此基础上辅以自体骨髓间充质神经干细胞移植治疗，首先抽取移植组患者骨髓并分离、培养骨髓间充质神经干细胞，待培养细胞达到治疗要求时进行神经干细胞移植治疗，共进行4次细胞移植治疗，每次间隔5～10d。于治疗前、治疗4周、治疗后3个月时分别采用神经功能缺损评分量表（CNS）、美国国立卫生研究院卒中量表（NIHSS）、Fugl—Meyer运动功能评定量表（FMA）及改良Barthel指数（MBI）评分对2组患者神经功能、肢体运动功能及日常生活活动（ADL）能力进行评定。结果经治疗4周及治疗后3个月时，发现2组患者CNS、NIHSS、MBI、上肢FMA及下肢FMA评分均较治疗前明显改善，并且治疗4周及治疗后3个月时移植组患者CNS评分[分别为（26．20±1．39）分、（17．14±1．64）分]、NIHSS评分[分别为（11．52±1．23）分、（9．51±1．05）分]、MBI评分[分别为（53．55±1．75）分、（60．09±2．17）分]、上肢FMA评分[分别为（34．60±2．08）分、（48．49±2．76）分]及下肢FMA评分[分别为（23．70±2．05）分、（30．41±2．32）分]改善幅度均显著优于对照组水平，组间差异均具有统计学意义（P〈0．05）；并且治疗过程中未发现移植组患者出现严重不良反应。结论自体骨髓间充质神经干细胞移植可促进脑梗死患者神经功能恢复，且治疗过程中未发现明显不良反应，安全性较好。
Objective To explore the curative effect and safety of transplanting autologous mesenchymal nervous system stem cells after cerebral infarction. Methods Fifty-eight patients with cerebral infarction were randomly divided into a control group and a research group with 29 cases in each. There was no statistically significant difference in terms of age, course, illness or treatment time between the groups. Mesenchymal nervous system stem cells were isolated from their bone marrow, cultured and administered as treatment. Before treatment and 4 weeks and 3 months after treatment, clinical nerve function limitation scores （CNS） were recorded, the National Institutes of Health Stroke Scale （NIHSS） and Fugl Meyer assessment （FMA） were administered, and the modified Barthel index （MBI） was evaluated. Results After 4 weeks and after 3 months the CNS and NIHSS scores in the research group were significantly lower than before treatment, and MBI and FMA scores were significantly higher. Compared with the controls, the CNS and NIHSS scores in the research group were significantly lower and the MBI and FMA scores were significantly higher after both 4 weeks and 3 months. Conclusion Transplanting autologous mesenchymal nervous system stem cells can safely improve nerve function after cerebral infarction.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2014年第6期425-428,共4页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
骨髓间充质神经干细胞
脑梗死
移植
自体
Bone marrow
M esenchyreal stem ceils
Nerve regeneration
Cerebral infarction
Transplantation
Autologous transplants
