摘要
4周龄雄性SD大鼠经高脂喂养8周后予小剂量链脲佐菌素腹腔注射以建立糖尿病模型,分为糖尿病组和瘤坏死因子相关的凋亡诱导配体（tumor necrosis factor-related apoptosis ligand,TRAIL）干预组,另选正常SD大鼠为对照组.TRAIL干预3个月.与糖尿病组相比,TRAIL干预组总胆固醇、甘油三酯、血糖、胰岛素显著降低,大鼠主动脉粥样斑块病变面积及光镜下内膜厚度减小[（23.8±5.7）％对（47.6±7.8）％].提示TRAIL可减轻糖尿病大鼠动脉粥样硬化病变.
Four-week-old male Sprague-Dawley rats were rendered diabetic by intraperitoneal injection of streptozotocin （STZ） after feeding high-fat-diet for 8 weeks,and divided into diabetes group and tumor necrosis factorrelated apoptosis ligand（TRAIL） group.Normal rats severed as a control group.Treatment with TRAIL lasted for 3 months.Total cholesterol,triglycerides,low-density lipoprotein-cholesterol,blood glucose,and insulin levels were decreased in TRAIL group,as compared with diabetes group.Area of atherosclerotic lesion in TRAIL group [（23.8 ± 5.7） ％] was significantly smaller than that in diabetes group [（47.6 ± 7.8） ％].It suggested that TRAIL may reduce the area of atherosclerotic lesion in diabetic rats.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2014年第6期519-522,共4页
Chinese Journal of Endocrinology and Metabolism
基金
湖北省自然科学基金重点项目（2011CDA002）
武汉市学科带头人计划（201271130459）
