摘要
目的分析射血分数保留的心力衰竭患者(HFPEF)的左心室舒张功能与N末端脑钠肽前体(NT-proBNP)的改变情况,并对以上指标进行初步评价。方法选取2009年12月至2013年3月入本院心内科及ICU的HFPEF患者66例以及心功能正常患者43例,测定两组患者左心室舒张功能参数及NT-proBNP,然后进行统计学分析。结果 HFPEF患者组与对照组相比,NTproBNP、LVMI、E/Em明显升高(P<0.05),两组患者E/Em与NT-proBNP值呈显著正相关(Pearson相关系数r为0.576)。结论 E/Em、NT-proBNP、LVMI三者均可反映HFPEF患者的舒张功能,上述指标对诊断HFPEF有一定参考价值。NT-proBNP cut-off取90pg/mL时对HFPEF具有较高的阴性预测值(92.7%)。
Objective To research the left ventricular diastolic echocardiographic parameters and NT-proBNP level in those patients with chronic heart failure with preserved ejection fraction（HF- PEF） and to evaluate the above index. Methods The study was a prospective, observational study. Sixty-six patients with HFPEF admitted in our hospital from December 2009 to March 2013 and forty-three patients with normal left ventricular diastolic function were examined and the NT-proBNP levels were determined simultaneously. Results Compared with control group, the HFPEF group had higher E/Era, NT-proBNP, LVMI （P〈0. 01）; NT proBNP correlated significantly with E/Em （correlation coefficient r= 0. 576）. Conclusion E/Era, NT-proBNP, LVMI can reflect the left ventricular diastolic function. When the cut-off of NT-proBNP was 90pg/mL, NT-proBNP had a significantly negative predictive value（92.7%）.
出处
《青岛医药卫生》
2014年第3期172-175,共4页
Qingdao Medical Journal
关键词
N末端脑钠肽前体
左心室舒张功能
射血分数保留的心力衰竭
NT-proBNP
Left ventricular diastolic function
Heart failure with preserved ejection fraction（HFPEF）
