摘要
目的:观察KKAy糖尿病小鼠的血糖、血脂变化,探讨益气养阴散结中药方对其糖脂代谢的影响。方法:选取雄性12周龄KKAy小鼠,将其随机分为模型组及中药组,同周龄雄性C57BL/6J小鼠为正常组。分别给药,中药组灌服益气养阴散结中药复方,模型组及正常组灌服等量蒸馏水,定期检测小鼠体重、血糖值,并分别于实验的第4、8、12周处死各组小鼠,检测三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇(HDL)等血脂指标。结果:KKAy小鼠的血糖、血脂水平在初期呈不断上升趋势,随着周龄的增长,血糖血脂有所下降,但仍显著高于正常组,益气养阴散结中药复方干预的小鼠血糖血脂水平有所回落。结论:KKAy小鼠存在明显的血脂异常,益气养阴散结中药复方可有效改善血脂异常情况,延缓糖尿病并发症的发生发展。
Objective：To observe the glucose and lipid metabolism in KKAy mice with type 2 diabetes and explore the effects of Yiqi Yangyin Sanjie herbal compound on dyslipidemia.Methods：The 12 -week-old male KKAy mice were randomly divided into model group and TCMgroup,and the same age of male C57BL/6J mice were chose as the normal group.The rats in different groups were trea-ted with relevant medicinal respectively by intragastrical method,as the TCM group were fed with Yiqi Yangyin Sanjie herbal compound, and the model group and normal group applied distilled water.The change of body weight and fasting blood glucose （FBG）were detec-ted.The levels of triglyceride （TG）,cholesterol （TC）,low-density lipoprotein cholesterol （LDL）,high density lipoprotein cholesterol （HDL）were detected after mice were sacrificed respectively at the end of 4th,8th and 12th weeks.Results：In model group,the levels of blood glucose and lipid levels showed a rising trend in the initial stage;with the weekly growth,the levels declined,but still signifi-cantly higher than that of the normal group.After the intervention of Yiqi Yangyin Sanjie herbal compound,blood glucose and lipid levels in mice had dropped slightly.Conclusion：There are significant dyslipidemia in KKAy mice,and Yiqi Yangyin Sanjie herbal compound can correct dyslipidemia effectively,and furthermore delay the development of diabetes complications.
出处
《世界中医药》
CAS
2014年第6期781-783,共3页
World Chinese Medicine
基金
高等学校博士学科点专项科研基金博导类(编号:20110013110004)
北京中医药大学自主选题项目在校研究生类(编号:2013-JYBZZ-XS-152)
关键词
糖尿病
益气养阴散结
KKAy
血脂异常
Diabetes
Yiqi Yangyin Sanjie herbal compound
KKAy mice
Dyslipidemia
