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不同剂量甲氨喋呤联合放疗治疗原发中枢神经系统淋巴瘤的临床效果 被引量：5

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摘要 回顾分析本院2008年10月20日-2012年10月30日的24例弥漫大B细胞淋巴瘤患者。24例患者均采用单药大剂量甲氨喋呤化疗六周期＋全脑放疗30Gy/15F,随机平均分为A、B两组,对照疗效OS、PFS及认知功能改变情况。化疗前及放疗结束后3个月均用蒙特利尔认知评估量表（MoCA）和简易智能状态检查量表（MMSE）进行认知功能评估。结果 A组12例,完全缓解6例,部分缓解1例,稳定4例,进展1例,中位生存期16（10-22）个月。B组12例,化疗后完全缓解7例,部分缓解5例,稳定0例,进展0例,B组中位生存期略长于A组,但两组生存曲线无明显差异,不具统计学意义（P〉0.05）,两组病例治疗前后认知功能评分均有轻度下降。更大剂量的甲氨喋呤化疗应用后可达更高的完全缓解率,放疗疗效及安全性均较好,是治疗PCNSL的首选方案。
作者 山常国 蔡林波 周青 甄俊杰 肖宵 王立超
机构地区 广东三九脑科医院
出处 《现代诊断与治疗》 CAS 2014年第6期1286-1287,共2页 Modern Diagnosis and Treatment
关键词 甲氨喋呤 中枢神经系统 淋巴瘤
分类号 R739.4 [医药卫生—肿瘤]
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现代诊断与治疗
2014年 第6期

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