摘要
目的探讨急性脑梗死患者脑动脉狭窄的分布特点及危险因素。方法 232例经MRI、MRA检查的脑梗死患者及健康对照者,存在狭窄患者根据狭窄部位分为单纯颅内狭窄组、单纯颅外狭窄组、颅内外狭窄组,分析脑动脉狭窄的分布特点及影响因素。结果 (1)单纯颅内动脉狭窄者114例(62.0%),单纯颅外动脉狭窄者30例(16.3%),合并颅内外动脉狭窄者40例(21.7%)。前循环狭窄(76.6%)比后循环(33.7%)常见。分别主要发生在MCA(64.4%)、PCA(53.8%)。(2)年龄、高血压、糖尿病、吸烟、纤维蛋白原(fibrinogen,Fbg)为脑动脉狭窄的独立危险因素(OR分别为1.049、10.063、3.873、3.311、6.085)。(3)高血压、糖尿病、吸烟为单纯颅内动脉狭窄的独立危险因素(OR分别为10.779、3.593、4.408),高血压、糖尿病、Fbg为单纯颅外动脉狭窄的独立危险因素(OR分别为6.143、8.179、2.410)。(4)合并颅内外动脉狭窄组CRP(C-reactive protein,C-反应蛋白)平均值显著高于单纯狭窄的两组(P=0.001、P=0.018),单纯狭窄组间比较无统计学意义。结论 (1)研究人群中脑动脉狭窄以颅内动脉狭窄为多见。(2)年龄、高血压、糖尿病、吸烟、Fbg为脑动脉狭窄的独立危险因素。(3)高血压、糖尿病为单纯颅内、颅外动脉狭窄共同的独立危险因素。吸烟为单纯颅内动脉狭窄的独立危险因素。Fbg为单纯颅外动脉狭窄的独立危险因素。(4)CRP可能为脑动脉狭窄的炎性预测因子。
Objective To investigate the distribution and risk factors of cerebral artery stenosis in patients with acute cerebral infarction. Methods There were 232 cases of cerebral infarction patients and healthy controls by MRI and MRA examination. The patients with arterial stenosis were divided into intracranial artery stenosis group,extracranial artery stenosis group, and combined stenosis group,to analyse the distribution and risk factors of cerebral artery stenosis. Results （1） Intracranial artery stenosis group were 114 cases （62. 0% ）, extracranial artery stenosis group were 30 cases （16.3%） ,intracranial and combined stenosis group were 40 cases （21.7%）. Anterior circulation stenosis （76.6%）were more common than Posterior circulation stenosis（33.7% ） , mainly occurred in MCA （64.4%） , PCA （53.8%） respectively. （2）Age, hypertension, diabetes, smoking, Fibrinogen （Fbg） were the independent risk factors in cerebrovascular stenosis. （ 3 ） Hypertension, diabetes, smoking, pure independent risk factors in intracranial artery stenosis, hypertension, diabetes, Fbg were the independent risk factors in extracranial artery stenosis. （4）Combined stenosis group had a significantly higher CRP average than the other two groups of pure stenosis （P = 0. 001 , P = 0. 018）. There were no statistically significant difference between two groups of pure stenosis. Conclusion （ 1 ） lntracranial artery stenosis is common in cerebral artery stenosis. （2）Age,hypertension,diabetes, smoking, Fbg are the independent risk factors of cerebral artery stenosis. （3）Hy- pertension,diabetes are the common risk factors of pure intraeranial and extracranial artery stenosis. Smoking is pure independent risk factors of intracranial artery stenosis. Fbg is pure independent risk factors of extracranial artery stenosis. （ 4 ） CRP is the relative inflammatory predictors of cerebral artery stenosis.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2014年第6期532-535,共4页
Journal of Apoplexy and Nervous Diseases
关键词
脑动脉狭窄
脑梗死血管分布
危险因素
Cerebral artery stenosis
Acute cerebral infarction
Vascular distribution
Risk factors
