摘要
原发性移植物功能衰竭(PGF)是心脏移植术后早期主要的死亡原因和并发症之一,临床表现为严重的右心、左心或全心功能衰竭,需要大剂量正性肌力药物、升压药物支持或机械循环辅助治疗。目前,因供器官显著短缺,更多的"边缘供心"被用于心脏移植,最终导致PGF发生率逐渐升高。已经证实供者年龄≥30岁、受者年龄≥60岁、术前受者对正性肌力药物依赖及供心缺血时间≥240 min等均为PGF发病的危险因素。改善供心保存策略以及移植前最优化匹配供、受者是预防和最大程度降低心脏移植术后早期PGF发生率的可行措施。
Primary graft failure （PGF） remains the leading cause of death and complications during early stage after heart transplantation; it manifests as severe right, left or biventricular dysfunction with requirements of high-dose inotropic agents as well as mechanical circulatory support. Under the circumference of significant organ shortages worldwide, increasingly utilized ＂marginal donors＂ has resulted in increased incidence of PGF. Multiple donor and recipient factors including donor age ≥ 30 years, recipient age ≥60 years, donor inotropic dependence and heart graft ischemic time ≥240 minutes have been identified as risk factors of PGF. Improvement of donor heart preservation strategies and careful matching of donors and recipients should be amenable in prevention and minimize incidence of PGF.
出处
《中华移植杂志（电子版）》
CAS
2014年第2期11-15,共5页
Chinese Journal of Transplantation(Electronic Edition)
