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多巴胺受体基因遗传多态性与精神分裂症的关联及法医学意义 被引量:2

Relationship between Genetic Polymorphism of Dopamine Receptor and Schizophrenia and Its Forensic Significance
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摘要 精神分裂症是一种常见的多因子参与的复杂疾病,司法精神病学鉴定中对精神分裂症的涉及甚多,但无有效的生物学鉴定指标。研究表明,多巴胺神经递质功能紊乱可能在精神分裂症的发生及其主要症状中发挥重要作用。本文综述了多巴胺受体的分类、基因结构以及近年来关于多巴胺受体基因遗传多态性与精神分裂症的关联研究及其法医学意义。 Schizophrenia is a common but complex mental disorder affected by multiple factors. Forensic psychiatric assessment of schizophrenia involves evaluations on many aspects, but there is no effective biological identification index for schizophrenia. Researches indicate that dysfunction of dopaminergic neurotransmission plays an important role in the pathogenesis of schizophrenia. Our study reviews the classification, genetic structure of dopamine receptors and the recent pertinent studies between the dopamine receptors and schizophrenia and its forensic significance.
作者 姚军 王保捷
出处 《法医学杂志》 CAS CSCD 2014年第3期202-206,共5页 Journal of Forensic Medicine
关键词 司法精神病学 精神分裂症 综述[文献类型] 受体 多巴胺 多态现象 遗传 forensic psychiatry schizophrenia review [publication type] receptors, dopamine polymor-phism, genetic
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参考文献36

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