摘要
目的 分析鸟司他丁在重症有机磷中毒患者治疗中对胆碱酯酶活性的影响。方法 研究资料来源于本院2008～2012年收治的36例重症有机磷中毒患者，以入院顺序将36例患者分成两组，对照组常规治疗，观察组采用乌司他丁治疗。分析治疗前后胆碱酯酶变化情况，研究两组并发症、住院时间、阿托品化时间。结果 两组患者入院时胆碱酯酶指标差异不明显（P〉0．05），治疗后观察组胆碱酯酶要明显高于对照组（P〈0．05）；观察组的住院时间、胆碱酯酶〈80％时间均要短于对照组，阿托品化时间要长于对照组，而并发症发生率要低于对照组（P〈0．05）。结论 在重症有机磷中毒患者治疗中应用乌司他丁，不会对胆碱酯酶产生抑制作用，而且能实现胆碱酯酶恢复，保护了患者的脏器功能。提高了临床治疗效果。
Objective Analysis the effect ofulinastatin on cholinesterase activity in patients with severe organophosphate poisoning. Methods Chose 36 patients with severe organophosphate poisoning in our hospital from 2008 to 2012 and divided into two groups. The observation group was treated with ulinastatin, the control group routine treatment, the observation group was treated with ulinastatin. The control group was treated with routine therapy. Results There were no significant difference between two groups in cholinesterase level on admission （ P〉0.05 ） . The cholinesterase level in observation group was obviously higher than control group. The length of hospital stay, time of cholinesterase〈80% are shorter, atropine time was longer in observation group, and the complication rate was lower in observation group Conclusion Ulinastatin therapy may not inhibit cholinesterase in patients with severe organophosphate poisoning, and it also protect patient＇s viscera function.
出处
《中国卫生标准管理》
2014年第2期5-7,共3页
China Health Standard Management
关键词
胆碱酯酶
乌司他丁
有机磷中毒
Cholinesterase
Ulinastatin
Organophosphate Poisoning
