摘要
DLC-1(肝癌缺失基因1)是近年来被发现的一种重要的抑癌基因,目前研究发现其在多种肿瘤的发生、发展过程中产生了重要的作用。随着基因技术及分子生物技术的飞速发展,关于DLC-1基因以及与之相关的上、下游靶基因,DLC-1基因的甲基化修饰及其相互作用的信号传导通路的研究将更深入、更彻底、更清楚。通过构建肿瘤动物实验模型,我们可以对人类各种肿瘤进行去甲基化药物治疗,分析实验结果,综合评估治疗指征,为临床上对肿瘤的治疗提供理论基础及实践指导。相信在不久的将来,针对DLC-1基因在肿瘤分子生物学研究有望成为多种肿瘤诊断、治疗的突破。
DLC-1 （deleted in liver cancer-l） is discovered as an important tumor suppressor gene in recent years. Present study finds it plays an important role in the occurrence and development of many kinds of tumors. With the rapid development of gene technology and molecular biotechnology, the research to gene methylation modification and interaction of signaling pathways about DLC-1 gene as well as the related upstream or downstream target genes will be deeper, more thoroughly and clearly. It can provide us theoretical basis and practice guidance of clinical treatment to tumor so that we could take various human tumor methylation drug treatment, analyze experimental results and take the comprehensive evaluation of treatment indications by building up tumor animal experimental model. It is believed,that the research aiming at DLC-l＇s molecular biology will be a breakthrough of varieties of tumors in diagnosis and therapy.
出处
《现代生物医学进展》
CAS
2014年第20期3970-3972,4000,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(31270532)
