期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

ATP合成酶的翻译后修饰 被引量：3

Post-Translational Modification of ATP Synthase
原文传递
导出
摘要 ATP合成酶(ATP synthase)是生物体内能量代谢的关键酶,是天然存在的分子旋转马达,为细胞生命活动提供所需能量,在生命体中具有重要作用。翻译后修饰(Post-translational modification,PTM)可改变蛋白的物理、化学性质、影响生物学活性,并调控许多生物反应过程,在某些病理情况下,ATP合成酶发生异常的翻译后修饰,导致机体损伤。 ATP synthase is a critical enzyme for numerous metabolic pathways in organism, acting as a natural rotary engine and it plays a very important role in life by providing the cells with usable energy. Post-translational modification （PTM） can regulate lots of biological processes by altering the structure and function of the protein. Under some pathological conditions, the PTM of ATP synthase may result in organism damage.
作者 赵婷 牛超 阮丹丹 南佳 丛维涛 金利泰
机构地区 温州医学院药学院
出处 《药物生物技术》 CAS 2014年第1期91-94,共4页 Pharmaceutical Biotechnology
基金 浙江省大学生科技创新活动计划 浙江省卫生高层次创新人才项目
关键词 ATP合成酶 翻译后修饰 磷酸化 硝基化 ATP synthase, Post-translational modification, Phosphorylation, Nitration
分类号 Q55 [生物学—生物化学]
  • 相关文献

参考文献30

  • 1Ackerman SH, Tzagoloff A. Function, structure, and biogenesis of mitochondrial ATP synthase[ J ]. Prog Nucleic Acid Res Mol Biol, 2005,80 : 95.
  • 2Garcla JJ, Morales-Rtos E, Cortes-Hernandez P. The inhibitor pro- tein ( IF1 ) promotes dimerization of the mitochondrial F1F0-ATP synthase [ J ]. Biochemistry, 2006,24 ( 42 ) : 12695.
  • 3Kranse F, Reifschneider NH, Goto S. Active oligomeric ATP syn- thases in mammalian mitochondria [ J ]. Biochem Biophys Res Commun,2005,329 ( 2 ) : 583.
  • 4王恩多.1997年度诺贝尔化学奖评介ATP合成酶和Na^+,K^+-ATP酶[J].科学,1998,50(1):60-62. 被引量：7
  • 5Garavelli JS. The RESID Database of Protein Modifications as a resource and annotation tool[ J ]. Proteomics,2004,4 (6) : 1527.
  • 6Hcjlund K, Wrzesinski K, Larsen PM, et al. Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes [J]. J Biol Chem,2003 ,278(12 ) :10436.
  • 7Reinders J, Wagner K, Zahedi RP, et al. Profilingphosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase [ J ]. Mol Cell Proteomics, 2007, 6 (11) :1896.
  • 8Di Pancrazio F, Bisetto E, Alverdi V, et al. Differential steady- state tyrosine phosphorylation of two oligomeric forms of mitochon-drial FOF1ATPsynthase: a structural proteomic analysis [ J]. Proteomics ,2006,6( 3 ) :921.
  • 9Kane LA, Youngman M J, Jensen RE, et al. Phosphorylation of the F1FOATP synthase beta subunit:functional and structural conse- quences assessed in a model system[ J ]. Circ Res,2010,106 ( 3 ) : 504.
  • 10Wu X, Oh MH, Schwarz EM, et al. Lysineacetylation is a wide- spreadprotein modification for diverseproteins in Arabidopsis [ J ]. Plant Physiol,2011,155 ( 4 ) : 1769.

共引文献6

同被引文献77

  • 1徐卫红.ATP合成酶及其功能机制综述[J].上饶师范学院学报,2004,24(3):36-40. 被引量：9
  • 2杨福愉.ATP合酶：一个最小的蛋白质分子转动马达[J].医学分子生物学杂志,2005,2(4):243-249. 被引量：16
  • 3舒咬根,欧阳钟灿.转动分子马达:ATP合成酶[J].自然杂志,2007,29(5):249-254. 被引量：12
  • 4Arnold I, Pfeiffer K, Neupert W, et al. 1988. Yeast mitochondrial F1Fo ATP synthase exists as a dimer: identification of three dimer specific subunits. EMBO J, 17 (24): 7170 -7178.
  • 5Boyer P D. 1997. The ATP synthase --a splendid molecular machine. Annu Rev Biochem, 66:717 - 749.
  • 6Cruz O M, Barca A M, Carvajal S U, et al. 2012. The function of mitochondrial FOF1 ATP-synthase from the white leg shrimp Litopenaeus vannamei muscle during hypoxia. Comparative Biochemistry and Physiology, 162 : 107 - 112.
  • 7Heazlewood J L, Whelan J, Millar A H. 2003. The products of the mitochondfial or'f25 and or fB genes are FO components in the plant F1 F0 ATP synthase. FEBS Letters,540:201 - 205.
  • 8Higuti J, Takeda A M, Paggi A C. 1993. Distribuiao espacia| das larvas de Chironomidae (Inseeta, Diptera) do rio Bala (MS-Brasil). Rev Unimar, 15 : 65 - 81.
  • 9Hong S, Pedersen P L. 2008. ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas. Microbiol Mol Biol Rev, 72:590- 641.
  • 10Kobayashi F, Yamane A, Ikeda T. 1984. The Japanese pine sawyer beetle as the vector of pine wilt disease. Annu Rev Entomol, 29: 115 - 135.

引证文献3

二级引证文献7

药物生物技术
2014年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部