摘要
目的观察干扰素α1b（赛若金）雾化吸入治疗毛细支气管炎的临床疗效。方法86例临床诊断为毛细支气管炎患儿单号入观察组42例，双号入对照组44例，观察组给予雾化吸入干扰素α1b20μg，每天2次；对照组给予雾化吸入利巴韦林50mg，每天2次；疗程均7d。观察两组患儿喘憋缓解及肺部哕音消失时间、发热消退时间、住院病程长短及有效率。结果一观察组喘憋缓解时间（t=1．756，P〈0．05）、肺部哕音消失时间（t=2．413，P〈0．01）、住院时间（t=2．547，P〈0．01）均少于对照组；观察组总有效率为88．0％（37／42），高于对照组的47．7％（21／44）（χ2=15．59，P〈0．01）；两组治疗中均未发现明显不良反应。结论干扰素α1b雾化吸入治疗毛细支气管炎疗效显著，值得临床推广应用。
Objective To study the effect and superiority of interferon used for treating bronchiolitis by aero- sol inhalation. Methods 86 patients with bronchiolitis were divided into the two groups, the therapy group with 42 cases,which were received 20μg interferon by aerosol inhalation two daily for 7 days ,the control group with 44 cases, which were given 50mg ribavirin by aerosol inhalation two daily for 7 days. The time of asthma and rales disappear in lungs and temperature decresing and hospitalization were observed. Results The time needed for the remission and disappearance of the major symptoms and physical signs like asthma and rales in the therapy group were significantly shorter than those in the control group, there were significant differences between the two groups （t = 2. 413,2. 547, all P 〈0.01 ）. The total effective rates of the therapy group was 88.0% （37/42） ,while of the control group was 47.7% （ 21/44 ）, there were significant differences （ χ2 = 15.59, P 〈 0.01 ）, no side effect was found. Conclusion Interferon can be effectively treated bronchiolitis by aerosol inhalation. It is worthy of application.
出处
《中国基层医药》
CAS
2014年第12期1795-1796,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
干扰素Α
投药
吸入
细支气管炎
婴儿
Interferon-alpha
Adiministration, inhalation
Bronchiolitis
Infant
