摘要
目的探讨盐酸氨溴索治疗昏迷患者肺部感染的临床效果,以期提高临床治疗水平,降低感染率。方法选取2011年8月-2013年5月118例昏迷发生肺部感染患者为研究对象,将其随机分为两组,对照组60例采用基础治疗,观察组58例予以基础治疗加盐酸氨溴索雾化吸入和静脉滴注治疗,比较两组治疗后临床效果;采用SPSS16.0软件进行统计分析。结果对照组治愈率为21.67%、显效率为35.00%、有效率为16.67%、总有效率为73.33%;观察组治愈率为65.52%、显效率为20.69%、有效率为8.62%、总有效率为94.83%,两组比较差异有统计学意义(P<0.05);两组患者住院时间、咳嗽缓解时间、体温恢复正常时间、昏迷好转时间、胸片阴影吸收时间、体征恢复时间、血常规正常时间比较差异有统计学意义(P<0.05);两组治疗后第7、10、14天在无创血氧饱和度(SaO2)和血氧分压(PO2)比较差异有统计学意义(P<0.05)。结论盐酸氨溴索治疗昏迷并肺部感染临床效果显著,安全性高。
OBJECTIVE To explore the clinical effect of ambroxol on treatment of pulmonary infections in the coma patients so as to improve the level of clinical treatment and reduce the infection rate.METHODS A total of 118coma patients with pulmonary infections who were treated in the hospital from Aug 2011to May 2013were enrolled in the study and randomly divided into two groups,then the control group with 60cases was treated with basic therapy,while the observation group with 58cases was given the basic therapy combined with nebulized inhalation of ambroxol hydrochloride and intravenous infusion,the therapeutic effect was compared between the two groups,and the statistical analysis was performed with the use of SPSS16.0software.RESULTS The cure rate was21.67%in the control group,65.52%in the observation group;the improvement rate was 35.00%in the control group,20.69%in the observation group;the effective rate was 16.67%in the control group,8.62%in the observation group;the total effective rate was 73.33%in the control group,94.83%in the observation group;there were significant differences（P〈0.05）.The difference in the hospitalization duration,cough relief time,time of body temperature returning to normal,coma improvement time,chest X-ray shadows absorption time,or time of blood routines＇ returning to normal between the two groups was significant（P〈0.05）;the difference in the noninvasive blood oxygen saturation（SaO2）or blood oxygen pressure on day 7,10,or 14between the two groups was significant（P〈0.05）.CONCLUSIONThe ambroxol can achieve significant clinical effect on treatment of pulmonary infections in the coma patients,with the safety high.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第14期3495-3496,3520,共3页
Chinese Journal of Nosocomiology
基金
河南省卫生厅专项支持计划基金资助项目(HW-2010B-048)
