摘要
首次报道了黑鲷口服土霉素的药物代谢动力学特征。用高效液相色谱法测定组织中的药物含量 ,药物在肌肉、血液、肝脏中的平均回收率分别为 85.61%、85.38%、82 .0 0 % ,该方法的检测限可达 0 .0 1μg/g。黑鲷 1次口服剂量为 75mg/kg的土霉素后 ,其血液药物浓度 -时间数据符合一室开放动力学模型 ,吸收速率常数 ( ka)为 0 .2 96/h、达峰时间 ( Tmax)为 10 .635h、峰浓度 ( Cmax)为 1.398μg/ml、分布半衰期 ( T1/2α)为 2 .339h、消除半衰期 ( T1/2β)为 4 6.663h,药时曲线下面积 ( AUC)为110 .2 5mg/L· h。黑鲷口服药物 0 .5h后在血液、肌肉、肝脏、肾脏 4种组织中就可以检测到药物的存在 ,药物在 16h的采样点浓度达最高 ,分别为 1.68μg/ml、1.68、2 .52、6.77μg/g。
This article is the first to report Pharmacokinetics property of OTC in Black seabream after oral administration. OTC concentration was determined by high efficient liquid chromatography.The result demonstrated: data of OTC concentrations versus time conformed to the open dynamic model of one compartment after a single oral administration at a dose of 75mg/kg, Absorption rate constant ( k a)was 0 296/h, Time to reach maximum concentration ( T max ) was 10 635h, Maximum concentration( C max )was 1 398μg/ml, Absorption half life( T 1/2α )was 2 339h, Elimination half life( T 1/2β )was 46 663h, Area under serum concentration (AUC) was 110 25mg/L·h, we could determine the concentration of OTC in four tissues (muscle, blood, liver and kinedy) after 0 5h for administration and the maximum concentration was 1 68、1 68、2 52、6 77μg/g respectively at 16h after administration,Average recoveries were 85 61%、85 38%、82 00% respectively in muscle,blood and liver, and the limit of determination was 0 01μg/g.
出处
《海洋水产研究》
CSCD
2001年第1期42-47,共6页
Marine Fisheries Research
基金
农业部科研项目!"渔用药物代谢动力学及药物残留的研究"资助
