摘要
目的 :研究反流性食管炎 (RE)患者胃酸和胆汁反流的发生情况 ,以探讨其发病机制和指导临床实践。 方法 :RE患者 85例 ,健康志愿者 2 0例作对照 ,应用便携式 p H计及胆汁监测仪同步监测食管 2 4h p H值变化及胆汁反流情况。结果 :RE患者胃酸及胆汁反流均较对照组显著增加 ;6 2 .4%的 RE患者存在胃酸及胆汁混合反流 ,单纯胃酸反流为 30 .6 % ,单纯胆汁反流为 3.5 % ,无任何反流为 3.5 % ;男女之间比较 ,各种反流无差别。 结论 :胆汁反流与胃酸反流常见于 RE患者 ,在胃食管反流病的发生中起重要作用 ,同步动态监测食管 p H值及胆汁变化对 RE的诊断有重要意义。
Objective: To study the incidence of acid and bile reflux in patients with reflux esophagitis(RE) and to evaluate the significance of detecting bile reflux in diagnosing RE. Methods: Using ambulatory 24 h pH monitoring bilirubin monitoring techniques, we simultaneously assessed the changes of intra esophgeal pH and bile reflux during 24 h in 105 subjects(including 85 patients with RE and 20 volunteers). Results: The time of esophageal acid exposure(pH<4) for RE patients was significantly greater than that for controls. Bile reflux, represented by total percentage time of bilirubin absorbance≥ 0.14 , was significantly greater for RE patients than that for controls. Neither acid nor bile reflux had difference between male and female. In RE patients, 62.4% had both acid and bile reflux; 30.6%, acid reflux; 3.5% , bile reflux; 3.5%, no reflux. Conclusion: Both acid and bile reflux are very common in RE patients and both may play roles in the development of RE. Simultaneously monitoring acid and bile reflux is very important in diagnosing RE. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2001年第3期207-209,共3页
Academic Journal of Second Military Medical University
基金
上海市卫生系统百人计划资助!项目 (98BR0 2 6 )
上海市青年科技启明星计划资助!项目 (99QB14 0 45 )
