摘要
观察了４６例妊高征（ＰＩＨ）患者红细胞滤过指数（ＩＦ）、红细胞ＡＴＰ酶和红细胞离子浓度的变化，并分析了其相互关系。结果表明，ＰＩＨ患者红细胞ＩＦ较正常对照组和正常孕妇明显增高（Ｐ＜０．００１）；红细胞Ｎ＋－Ｋ＋－ＡＴＰ酶、Ｃａ～（２＋）－Ｍｇ～（２＋）－ＡＴＰ酶活性和红细胞Ｋ＋、Ｍｇ～（２＋）浓度明显降低，红细胞Ｃａ～（２＋）、Ｎａ＋浓度明显增高，与对照组和正常孕妇相比，差异均有显著性（Ｐ＜０．００１），而且这些变化随ＰＩＨ病情加重而逐渐明显。ＰＩＨ患者红细胞ＩＦ与红细胞Ｎａ＋－Ｋ＋－ＡＴＰ酶，Ｃａ～（２＋）－Ｍｇ＋ＡＴＰ酶活性及红细胞Ｋ＋、Ｍｇ～（２＋）浓度呈负相关（Ｐ＜０．００１），与红细胞Ｃａ～（２＋）、Ｎａ＋浓度呈正相关（Ｐ＜０．００１）。提示ＰＩＨ患者红细胞变形能力降低与红细胞ＡＴＰ酶活性及红细胞内离子浓度变化有关。
The erythrocyte index of filtration (IF) and erythrocyte ATPase activities as well as intraerythrocytic ionic concentration were observed in 46 patients with pregnancy jnduced hypertension (PIH).The results showed that the IF was significantly higher in PIH patients than that in the control and normal pregnancy women (P<0. 001), the activities Of Na+-K+-ATPase, Ca(2+)-Mg(2+)-ATPase and intra- erythrocyt ic K+ ,Mg(2+) concentrations were all significantly lower than that in the control and normal pregnancy women (P<0.001), but intraerythrocytic Ca(2+), Na(2+) concentrations were significantly higher (P <0. 001). These. variations were more obvious with the development of PIH. In PIH patients the erythrocyte IF was negatively correlated with Na(2+)K+ -ATPase, Ca(2+)- Mg(2+) - ATP-ase activities and intra-erythrocytic K+, Mg(2+) concentrations. There was positively correlation between IF and Ca(2+), Na+ concentrations. These results indicated that decreasing of ED in PIH patients was related to decreasing of erythrocyte ATPase activities and changes of intra-erythrocytic ionic concentrations .
出处
《现代妇产科进展》
CSCD
1994年第4期320-323,共4页
Progress in Obstetrics and Gynecology
关键词
妊娠高血压
综合征
红细胞
离子
腺苷三磷酸酶
Piegnancy induced hypertension
Erythrocyte deformability
Erythrocyte ATPase
Erythrocyte ions
