摘要
目的 观察大剂量静脉注射免疫球蛋白 (IVIG)治疗儿童系统性红斑狼疮 (SLE)的疗效。方法 6 9例SLE患儿随机分成两组 ,IVIG组 33例用大剂量IVIG和激素及环磷酰胺 (CTX) ;对照组 36例用激素和CTX治疗。观察大剂量IVIG对SLE疾病活动指数 (SLEDAI)、临床表现和SLE血清学指标的影响。结果 IVIG组治疗 3个月后SLEDAI明显低于对照组 (P <0 0 1) ,在降低蛋白尿、ANA及抗dsDNA抗体以及控制院内感染、病情稳定方面显著优于对照组。结论 大剂量IVIG是治疗儿童SLE有效的辅助措施。
Objective To investigate the effect of high dose intravenous immunoglobulins (IVIG) on children with systemic lupus erythematosus.Methods Sixty nine patients were randomly divided into two groups:33 (IVIG group) were treated by high dose IVIG in combination with prednisone and cyclophosphamide, and 36 (control group) treated by prednisone and cyclophosphamide.Results SLE disease activity index (SLEDAI) was 14 6±3 5 before treatment and 3 5±2 8 after 3 month treatment in IVIG group,and 13 1±4 3 and 7 8±3 8 respectively in control group ( P <0 01).IVIG group had better results than those of control one,including a decline in proteinuria,antinuclear antibodies,dsDNA antibodies and the morbidity of hospital infection.Conclusion High dose IVIG is a potent adjuvant therapy for children with SLE.
出处
《中华风湿病学杂志》
CAS
CSCD
2001年第2期110-112,共3页
Chinese Journal of Rheumatology
