摘要
为了解原发性血小板减少性紫癜患儿血小板平均容积（ＭＰＶ）、血小板压积（ＰＣＴ）及血小板分布宽度（ＰＤＷ）的变化及其临床意义，采用全自动血细胞分析仪测定原发性血小板减少性紫癜患儿血小板数目、ＭＰＶ、ＰＣＴ、ＰＤＷ，以健康儿童作为对照。结果显示：原发性血小板减少性紫癜患儿极期 ＭＰＶ增大，ＰＣＴ降低，与对照组比较有统计学差异（Ｐ＜０．０５），ＰＤＷ无明显变化（Ｐ＞０．０５）；经治疗后恢复期 ＭＰＶ变小，ＰＣＴ增大，与对照组比较无明显差异。轻、中、重度ＩＴＰ患儿随病情的加重，ＭＰＶ逐渐增大，ＰＣＴ变小，极重度 ＩＴＰ患儿 ＭＰＶ变小，经统计学处理，差异有显著性（Ｐ＜０．０５），ＰＤＷ无明显变化（Ｐ＞０．０５）。ＭＰＶ与血小板计数呈负相关，ＰＣＴ与血小板数量呈正相关（Ｐ＜０．０５）。因而，原发性血小板减少性紫癜患儿除血小板数量减少外，还存在血小板平均容积、血小板压积的改变，其可作为判断病情的一个有用指标。
To investigate the parameters of platelet in children with idopathic thrombocytopenic purpura (ITP) Methods The values of platelet count, mean platelet volume (MPV), platele- crit (PCT), platelet distribution width (PDW) were measured in 40 children with ITP and 38 normal controls. Results Compared with control group, the values of MPY were higher, PCT were lower in children with ITP (P＜0. 05). There were no statistically difference in PDW. But there were no significant differences in these values between ITP children in re- covery stage and control group. The abnormalities of the platelet parameters becomes signifi- cant with the procession of ITP stages. The platelet count is negative associated with the values of MPV, positive associated with the values of PCT (P<0. 05). Conclusion In addi- tion to the changes of platelet count, there is abnormality of MPV and PCT in children with ITP. It is helpful to measure MPV and PCT in children with ITP.
出处
《中国小儿血液》
2001年第2期54-57,共4页
China Child Blood
