摘要
目的 应用成本 效果分析对部队不同乙型肝炎 (乙肝 )疫苗接种方案进行比较 ,为制定经济有效的全军乙肝疫苗预防接种策略提供依据。方法 建立决策树和乙肝转归树 ,采用催化模型推算不同接种方案下易感人群年新感染率 ,用失能调整生命年 (disability adjustedlifeyear ,DALY)作为衡量效果的指标 ,计算增量成本效果比。结果 与不接种方案相比 ,直接接种方案和筛检再接种方案的DALY分别为 6 1.888和 5 7.175 ,增量成本效果比 (cost effectivenessratio ,CER)分别为 392 .70和2 5 1.90。用部队干部实际年龄构成进行加权 ,得到筛检再接种方案和直接接种方案的CER分别为2 5 1.9和 392 .7,即每获得一个健康生命年所需成本前者少于后者。结论 筛检再接种方案优于直接接种方案 ;
Objective To select an optimal vaccination approach and provide basis for decision making on the control of hepatitis B infection in PLA. Methods Decision trees were constructed. The yearly new infection rate in susceptible cohort, using a catalytic model, was estimated. Disability adjusted life year (DALY) was used to assess the effectiveness. Incremental cost effectiveness ratio (CER) was then calculated. Results Compared with no vaccination, DALY of immediate vaccination and vaccination after screening were 61.89 and 57.18 with CER 392.70 and 251.90 respectively. After weighting with actual age construction of PLA population, the CERs of vaccination after screening and immediate vaccination were 251.90 and 392.70 respectively. Conclusion The results indicated that screening followed by vaccination was superior to immediate vaccination approach. The younger the vaccination was carried out, the more cost effective was shown by vaccination.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2001年第2期142-145,共4页
Chinese Journal of Epidemiology
