期刊文献+

大口径毛细管气相色谱检查药物中残留溶剂的方法研究 被引量:14

Study on Gas Chromatographic Method for the Evaluation of Residual Solvents by Using Wide Bore Open Tubular Columns
下载PDF
导出
摘要 以药物合成中常用的 16种有机溶剂为研究对象 ,建立了用大口径毛细管柱检查残留有机溶剂的气相色谱法 ,并考察了不同极性的色谱柱及不同提取溶剂对分离与检测的影响。实验表明 ,根据原料药合成中可能存在的残留溶剂 ,选用适当的提取溶剂 ,采用大口径毛细管气相色谱法检查 ,可获得较满意的结果。 A GC method using wide bore open tubular columns was developed to evaluate residual organic solvents. Sixteen organic solvents commonly used for pharmaceutical synthesis were analysed.The effects of different polarity columns and extraction solvents on the assay of residual solvents were studied in this work. It showed that most solvents can be well separated from each other on non polar or less polar wide bore columns. Extraction solvents differed in their extraction recovery and peak shape. Satisfactory results can be obtained when the proposed method was employed and a suitable extraction solvent was selected.The procedures summarized in this paper can be used as a guidance for the evaluation of residual organic solvents in bulk pharmaceuticals.
出处 《色谱》 CAS CSCD 北大核心 2001年第2期141-143,共3页 Chinese Journal of Chromatography
关键词 大口径毛细管柱 气相色谱 残留溶剂 药物合成 检测方法 wide bore open tubular column gas chromatography residual solvents
  • 相关文献

参考文献3

二级参考文献1

  • 1庄如宝,医药工业,1980年,12卷,17页

共引文献7

同被引文献137

引证文献14

二级引证文献63

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部