摘要
螺旋藻多糖200mg/kg可显著抑制小鼠体内腹水型肝癌细胞的增殖。它对S180和腹水型肝癌细胞DNA,RNA和蛋白质的抑制作用,在3～24h内均随作用时间延长而提高。它对癌细胞DNA合成的抑制作用,属DNA代谢干扰型。螺旋藻多糖虽不能直接杀伤癌细胞,但通过增强机体的免疫力而抑制癌细胞的增殖。
Polysaccharide of Spirulina platensis can inhibit the proliferation of ascitic hepatoma cells of mice in the concentration of 200 mg/kg. It can inhibit the incorporation of 3H-thymidine, 3H-uridine and 3H-leucine into DNA, RNA and protein synthesis of sarcoma 180 and ascitic hepatoma cells during the period of 24 h after exposure in vetro. The degree of inhibition increases with the extending of incubation time. Polysaccharide of Spirulina pla-tensis can inhibit DNA synthesis of sarcoma 180 and ascitic hepatoma cells. The mechanism of inhibition belongs to DNA metabolism disturbance.
出处
《海洋科学》
CAS
CSCD
北大核心
1991年第5期33-38,共6页
Marine Sciences
关键词
癌细胞
移植性
抑制作用
螺旋藻
Polysaccharide of Spirulina platensis, Ascitic hepatoma sarcoma 180, 3H-thymidine,3H-uridine, 3H-leucine
