摘要
泽泻合剂是由利尿活血中药组成的制剂,经临床观察对美尼尔氏病患者能消除内耳膜迷路水肿,改善患者纯音测听及电耳蜗图,经77例观察,其纯音测听改善者55例,占63.7%,电耳蜗图改善者占82.6%,与目前常用的甘油脱水试验结果相同,副作用明显少于甘油,故泽泻合剂可取代甘油作美尼尔氏病诊断和治疗之用。
Rhizoma Alismatis Mixture(RAM),which can promote diuresis to eliminate wetness-evil and activate blood circulation,is a pure TCM preparation composed of Rhizoma Alismatis,Semen Plantaginis,Rhizoma Ligustici Wallichii and Herba Leonuri.After clinical observation,it showed that RAM can greatly ease the inner ear edema of patients with Meniere's disease and therefore improved their hearing threshold (63.7%).RAM can also diminish SP amplitude or reduce the SP/ AP ratio on the cochleogram.As compared with glyceral test,there was no statistically significant difference,while the side effect of RAM group(5%) was lower than that of glyceral group (87.3%) significantly,therefore RAM test can replace glycerin test in the diagnosis of Meniere's disease.The animal experiment results indicated that RAM did not affect stria vascularis permeation but it probably dehydrates the inner ear by changing the osmotic pressure between endolymphatic and perilymphatic or increasing the absorption of the endolymphatic sac.
关键词
泽泻合剂
美尼尔氏病
纯音测听
电耳蜗图
内耳脱水
诊断
Rhizoma Alismastic Mixture
Meniere's disease
audiometry
cochleogram
dehydrate the inner ear
