期刊文献+

肿瘤组织中GST-π基因的RT-PCR定量研究 被引量:5

QUANTITATIVE ANALYSIS OF THE GST-π IN LUNG CANCER BY RT-PCR
下载PDF
导出
摘要 应用RT PCR技术对 5 1例肺癌手术标本及对应的癌旁组织中GST π基因的表达情况进行定量研究。结果表明 ,在癌变组织中GST π的表达明显高于癌旁组织 ,且与临床病理类型、分期及分化程度无关 ,对临床化疗方案的制订具有一定的指导意义。该组患者术前未经抗癌治疗 ,提示肺癌先天性耐药中GST Expression of the GST-π in 51 cases of lung cancer was researched by quantitative RT-PCR. The results suggested that the expression of GST-π was significantly higher in lung cancer than in normal tissues adjacent to cancer, and tumoral native resistance might be dominant in tumoral resistance to chemotherapeutic drugs. No relationship was found between GST-π expression and clinicopathological parameters including tumor class, stage and differentiation. The study of GST-π expression is of importance in the evaluation of tumoral resistance to anticancer drugs.
出处 《解放军医学杂志》 CAS CSCD 北大核心 2001年第4期272-274,共3页 Medical Journal of Chinese People's Liberation Army
关键词 肺肿瘤 GST-Π 抗药性 基因表达 RT-PCR lung neoplasms GST-π drug resistance gene expression
  • 相关文献

参考文献6

  • 1金冬雁 黎孟枫译.分子克隆实验指南(第二版)[M].北京:科学出版社,1995.343.
  • 2汲言山 郭静云 等.多药耐药基因与白血病化疗[J].中华流行病学杂志,1992,13:2-2.
  • 3戴广海,石廷章,李春海.肺癌组织MDR1和GST-πmRNA水平测定及其临床意义[J].解放军医学杂志,1998,23(2):108-110. 被引量:3
  • 4金冬雁(译),分子克隆实验指南(第2版),1995年,343页
  • 5卢圣栋,现代分子生物学实验技术,1993年,205页
  • 6汲言山,中华流行病学杂志,1992年,13卷,特刊,2页

二级参考文献1

  • 1金冬雁,分子克隆实验指南(第2版),1995年,343页

共引文献8

同被引文献38

  • 1Li, Shi-Yong,An, Ping,Cai, Hui-Yun,Bai, Xue,Zhang, Ying-Nan,Yu, Bo,Zuo, Fu-Yi,Chen, Gang.Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma[J].Hepatobiliary & Pancreatic Diseases International,2010,9(2):149-153. 被引量:4
  • 2李榕,韩宝惠.肺癌化疗中铂类药物耐药性检测的研究进展[J].临床肿瘤学杂志,2004,9(3):310-313. 被引量:3
  • 3高振强,高志萍.肺癌分子生物学研究进展[J].国外医学(呼吸系统分册),1996,16(2):92-96. 被引量:6
  • 4Hida T, Kuwabara M, Ariyoshi Y, et al. Serum glutathione S-transferase-π level as a tumor marker for non-small cell lung cancer[ J].Cancer, 1994,73 : 1377 - 1382.
  • 5Innis MA, Gelfand DH, Sninsky JJ, et al. PCR protocols : a guide to methods and applications [ M ]. San Diego : Academic Press, 1990 :482.
  • 6戴广海 石延章 李春海 等.肺癌患者血浆GST—π水平测定及其临床意义[J].中华肿瘤杂志,1997,19:357-357.
  • 7Bai F,Nakanishi Y.Immunohistochemical expression of GSTPi can predict chemotherapy response in patients with NSCLC[J].Cancer,1996,78(3):1025-1027.
  • 8Arai T,Yasuda Y.Immunohistochemical expression of GSTPi in untreated primary NSCLC[J].Cancer Detect Prev,2000,24(3):1411-1423.
  • 9秦芳 秦露 张霞 等.P-GP,GSTs,topoⅡ在胃癌组织中的表达.癌症,2002,21(2):363-365.
  • 10Jayasurya A,Yap W M,Tan N G,et al.Glutathione S-trasferases-Pi espression in nasopharyngeal cancer[J].Arch Otolaryngol Head Neck Surg,2002,128(12):1396-1399.

引证文献5

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部