摘要
^(131)I-胆酰甘氨酰酪氨酸(CGT)被用于裸大鼠人肝癌放射性定位和实验治疗的研究。在静注^(131)Ⅰ—CGT后所定时间内处死裸大鼠,并测定其主要脏器的放射性。^(131)Ⅰ-CGT在肿瘤中的摄取率显著地高于其他组织,特别在24h时相。注射24h后,在3只大鼠中均可见清晰的肿瘤显像。裸大鼠肝癌模型的动态扫描表明,肝癌能选择性地摄取^(131)I-CGT,并滞留达7天。经治疗的6只大鼠中,3个月后观察,其中1只鼠的肿瘤完全消退,其余的部分消退。
131I-Cholylglycyltyrosine (CGT) was used for the study of radiolocalization and targeting therapy in nude rats bearing human hepatocellular carcinoma (HCC) (nude rat-HCC). The nude rats were sacrificed at various intervals after intravenous injection of 131I-CGT, and radioactivity in major organs was determined. The uptake rate of 121I-CGT in tumor was remarkably higher than that of other tissues, especially on the phase of 24 hours. Tumor imaging was clearly observed 24 hours after the injection in all of the three rats. Dynamic scanning in nude rat-HCC model showed that 131I-CGT can be selectively taken up by hepatoma, and detained up to 7 days. Of the six rats treated, complete remission was observed in one rat three months later, while partial remission observed in the others.
出处
《核技术》
CAS
CSCD
北大核心
1991年第5期273-276,共4页
Nuclear Techniques
关键词
碘131
CGT
肝癌
放射疗法
定位
Cholylglycyltyrosine (CGT) Nude rat Hepatocellularcarcinoma (HCC) Radiolocalization Dynamic scanning
